Magnitude and associated factors of latent tuberculosis infection due to Mycobacterium tuberculosis complex among high-risk groups in urban Bobo-Dioulasso, Burkina Faso.

Autor:	Djibougou DA; Ecole Doctorale Sciences Naturelle et Agronomie, Université Nazi BONI, Bobo-Dioulasso, Burkina Faso.; Programme des Maladies Infectieuse, Centre MURAZ/Institut National de Santé Publique, Bobo-Dioulasso, Burkina Faso., Mensah GI; Department of Bacteriology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana., Sagna T; Centre National de Recherche Scientifique et Technologique/Institut de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso., Sawadogo LT; Programme National Tuberculose, Ministry of Health, Ouagadougou, Burkina Faso., Ouedraogo AK; Programme des Maladies Infectieuse, Centre MURAZ/Institut National de Santé Publique, Bobo-Dioulasso, Burkina Faso., Kabore A; Programme des Maladies Infectieuse, Centre MURAZ/Institut National de Santé Publique, Bobo-Dioulasso, Burkina Faso., Hien H; Programme des Maladies Infectieuse, Centre MURAZ/Institut National de Santé Publique, Bobo-Dioulasso, Burkina Faso.; Centre National de Recherche Scientifique et Technologique/Institut de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso., Meda CZ; Programme des Maladies Infectieuse, Centre MURAZ/Institut National de Santé Publique, Bobo-Dioulasso, Burkina Faso.; Institut Superieur des Sciences de la Santé, Université Nazi BONI, Bobo-Dioulasso, Burkina Faso., Combary A; Programme National Tuberculose, Ministry of Health, Ouagadougou, Burkina Faso., Belem AM; Ecole Doctorale Sciences Naturelle et Agronomie, Université Nazi BONI, Bobo-Dioulasso, Burkina Faso., Addo KK; Department of Bacteriology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Accra, Ghana., Dabiré RK; Centre National de Recherche Scientifique et Technologique/Institut de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso., Perreau M; Faculty of Biology and Medicine, Université de Lausanne, Lausanne, Switzerland., Zinsstag J; Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland., Diagbouga SP; Centre National de Recherche Scientifique et Technologique/Institut de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso.
Jazyk:	angličtina
Zdroj:	IJID regions [IJID Reg] 2022 May 14; Vol. 4, pp. 1-9. Date of Electronic Publication: 2022 May 14 (Print Publication: 2022).
DOI:	10.1016/j.ijregi.2022.05.004
Abstrakt:	Objectives: To determine the prevalence and risk factors for latent tuberculosis infection (LTBI) among three high-risk groups - household contacts of TB index cases, healthcare workers and slaughterhouse workers - in Bobo-Dioulasso, Burkina Faso. Methods: Participants were recruited to this cross-sectional study from March to July 2020 after giving informed consent. Sociodemographic, clinical and biological data were collected using a structured questionnaire. The QuantiFERON-TB Gold Plus test (QFT-Plus) and the tuberculin skin test (TST) were used for detection of LTBI. Bivariate and multivariate logistic regression analyses were performed to identify risk factors for LTBI. Results: The prevalence of LTBI among 101 participants (age range 15-68 years) was 67.33% [95% confidence interval (CI) 57.27-76.33] and 84.16% (95% CI 75.55-90.66) based on QFT-Plus and TST results, respectively. Compared with healthcare workers and household contacts of TB index cases, the prevalence of LTBI among slaughterhouse workers was significantly higher for both QTF-Plus (96.8%; P <0.001) and TST (100%; P =0.003). Working in a slaughterhouse [adjusted odds ratio (AOR) 1.095, 95% CI 1.00-2.036], smoking (AOR 4.214, 95% CI 1.051-16.899), ≥15 years of exposure (AOR 5.617, 95% CI 1.202-32.198), having an animal at home (AOR 2.735, 95% CI 1.102-6.789) and protozoal infection (AOR 2.591, 95% CI 1.034-6.491) were significantly associated with LTBI on the QFT-Plus assay. Conclusion: The prevalence of LTBI was high in all three groups, particularly slaughterhouse workers. The risk factors identified could form the basis of targeted intervention. Competing Interests: None declared. (© 2022 The Author(s).)
Databáze:	MEDLINE
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