Molecular characterization, clinical relevance and immune feature of m7G regulator genes across 33 cancer types.

Autor:	Li Z; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China., Li Y; Department of Nursing, Xiangya Hospital, Central South University, Changsha, China., Shen L; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China., Shen L; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China., Li N; Department of Oncology, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Jazyk:	angličtina
Zdroj:	Frontiers in genetics [Front Genet] 2022 Aug 25; Vol. 13, pp. 981567. Date of Electronic Publication: 2022 Aug 25 (Print Publication: 2022).
DOI:	10.3389/fgene.2022.981567
Abstrakt:	Over 170 RNA modifications have been identified after transcriptions, involving in regulation of RNA splicing, processing, translation and decay. Growing evidence has unmasked the crucial role of N 6 -methyladenosine (m6A) in cancer development and progression, while, as a relative newly found RNA modification, N 7 -methylguanosine (m7G) is also certified to participate in tumorigenesis via different catalytic machinery from that of m6A. However, system analysis on m7G RNA modification-related regulator genes is lack. In this study, we first investigated the genetic alteration of m7G related regulator genes in 33 cancers, and found mRNA expression levels of most regulator genes were positively correlated with copy number variation (CNV) and negatively correlated with methylation in most cancers. We built a m7G RNA modification model based on the enrichment of the regulator gene scores to evaluate the m7G modification levels in 33 cancers, and investigated the connections of m7G scores to clinical outcomes. Furthermore, we paid close attention to the role of m7G in immunology due to the widely used immune checkpoint blockade therapy. Our results showed the higher m7G scores related to immunosuppression of tumor cells. Further confirmation with phase 3 clinical data with application of anti-PDL1/PDL indicated the impact of m7G modification level on immunotherapy effect. Relevance of m7G regulator genes and drug sensitivity was also evaluated to provide a better treatment choice when treating cancers. In summary, our study uncovered the profile of m7G RNA modification through various cancers, and figured out the connection of m7G modification levels with therapeutical outcomes, providing potential better options of cancer treatment. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Li, Li, Shen, Shen and Li.)
Databáze:	MEDLINE
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