Injectable, dispersible polysulfone-polysulfone core-shell particles for optical oxygen sensing.

Autor: Presley KF; Department of Materials Science and Engineering, The Ohio State University, 116 W 19th Avenue, Columbus, OH 43210, USA., Fan F; Department of Materials Science and Engineering, The Ohio State University, 116 W 19th Avenue, Columbus, OH 43210, USA; Center for Chronic Brain Injury Program, The Ohio State University, Columbus, OH 43210, USA., DiRando NM; Department of Materials Science and Engineering, The Ohio State University, 116 W 19th Avenue, Columbus, OH 43210, USA., Shahhosseini M; Department of Mechanical and Aerospace Engineering, The Ohio State University, 201 W 19th Avenue, Columbus, OH 43210, USA., Rao JZ; Department of Materials Science and Engineering, The Ohio State University, 116 W 19th Avenue, Columbus, OH 43210, USA., Tedeschi A; Center for Chronic Brain Injury Program, The Ohio State University, Columbus, OH 43210, USA; Department of Neuroscience, Wexner Medical Center, The Ohio State University, 460W 12th Avenue, Columbus, OH 43210, USA., Castro CE; Department of Mechanical and Aerospace Engineering, The Ohio State University, 201 W 19th Avenue, Columbus, OH 43210, USA., Lannutti JJ; Department of Materials Science and Engineering, The Ohio State University, 116 W 19th Avenue, Columbus, OH 43210, USA; Center for Chronic Brain Injury Program, The Ohio State University, Columbus, OH 43210, USA.
Jazyk: angličtina
Zdroj: Journal of applied polymer science [J Appl Polym Sci] 2021 Jul 05; Vol. 138 (25). Date of Electronic Publication: 2021 Feb 11.
DOI: 10.1002/app.50603
Abstrakt: Injectable sensors can significantly improve the volume of critical biomedical information emerging from the human body in response to injury or disease. Optical oxygen sensors with rapid response times can be achieved by incorporating oxygen-sensitive luminescent molecules within polymeric matrices with suitably high surface area to volume ratios. In this work, electrospraying utilizes these advances to produce conveniently injectable, oxygen sensing particles made up of a core-shell polysulfone-polysulfone structure containing a phosphorescent oxygen-sensitive palladium porphyrin species within the core. Particle morphology is highly dependent on solvent identity and electrospraying parameters; DMF offers the best potential for the creation of uniform, sub-micron particles. Total internal reflection fluorescence (TIRF) microscopy confirms the existence of both core-shell structure and oxygen sensitivity. The dissolved oxygen response time is rapid (<0.30 s), ideal for continuous real-time monitoring of oxygen concentration. The incorporation of Pluronic F-127 surfactant enables efficient dispersion; selection of an appropriate electrospraying solvent (DMF) yields particles readily injected even through a <100 μm diameter needle.
Databáze: MEDLINE
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