Validity of the peak velocity to detect physical training improvements in athymic mice.

Autor: Kraemer MB; Research Group on Technology Applied to Exercise Physiology (GTAFE), Laboratory of Multidisciplinary Research, São Francisco University, Bragança Paulista, Brazil., Silva KC; Research Group on Technology Applied to Exercise Physiology (GTAFE), Laboratory of Multidisciplinary Research, São Francisco University, Bragança Paulista, Brazil., Kraemer CCF; Research Group on Technology Applied to Exercise Physiology (GTAFE), Laboratory of Multidisciplinary Research, São Francisco University, Bragança Paulista, Brazil., Pereira JS; Research Group on Technology Applied to Exercise Physiology (GTAFE), Laboratory of Multidisciplinary Research, São Francisco University, Bragança Paulista, Brazil., Dos Reis IGM; Research Group on Technology Applied to Exercise Physiology (GTAFE), Laboratory of Multidisciplinary Research, São Francisco University, Bragança Paulista, Brazil., Priolli DG; Coloproctology Service of the Federal University of São Paulo, São Paulo and Faculty of Health Sciences Pitágoras de Codó, São Paulo, Brazil., Messias LHD; Research Group on Technology Applied to Exercise Physiology (GTAFE), Laboratory of Multidisciplinary Research, São Francisco University, Bragança Paulista, Brazil.
Jazyk: angličtina
Zdroj: Frontiers in physiology [Front Physiol] 2022 Aug 24; Vol. 13, pp. 943498. Date of Electronic Publication: 2022 Aug 24 (Print Publication: 2022).
DOI: 10.3389/fphys.2022.943498
Abstrakt: This study comprises two complementary experiments with athymic Balb/c (Nu/Nu) mice. In experiment 1, the aim was to verify the reproducibility of the peak velocity (V Peak ) determined from the incremental test. The second experiment aimed to assess the V Peak sensitivity to prescribe and detect modulations of the physical training in athymic nude mice. Sixteen mice were submitted to two incremental treadmill tests separated by 48-h (Experiment 1). The test consisted of an initial warm-up of 5 minutes. Subsequently, animals initiated the tests at 8 m min -1 with increments of 2 m min -1 every 3 minutes. The V Peak was determined as the highest velocity attained during the protocol. In experiment 2, these animals were randomly allocated to an exercise group (EG) or a control group (CG). The training protocol consisted of 30-min of treadmill running at 70% of the V Peak five times a week for 4 weeks. High indexes of reproducibility were obtained for V Peak (Test = 19.7 ± 3.6 m min -1 ; Retest = 19.2 ± 3.4 m min -1 ; p = 0.171; effect size = 0.142; r = 0.90). Animals from the EG had a significant increase of V Peak (Before = 18.4 ± 2.7 m min -1 ; After = 24.2 ± 6.0 m min -1 ; p = 0.023). Conversely, a significant decrease was observed for the CG (Before = 21.1 ± 3.9 m min -1 ; After = 15.9 ± 2.7 m min -1 ; p = 0.038). The V Peak is a valid parameter for exercise prescription in studies involving athymic nude mice.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Kraemer, Silva, Kraemer, Pereira, dos Reis, Priolli and Messias.)
Databáze: MEDLINE
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