Assessment of therapeutic potential of Allium sativum and Zingiber officinale commercial supplements in experimental giardiasis models.

Autor: Eissa FMA; Department of Medical Parasitology, Faculty of Medicine, Cairo University, Al-Saray St., El Manial, Cairo, 11956 Egypt., Abdel-Shafi IR; Department of Medical Parasitology, Faculty of Medicine, Cairo University, Al-Saray St., El Manial, Cairo, 11956 Egypt., El-Sayed SH; Department of Medical Parasitology, Faculty of Medicine, Helwan University, Cairo, Egypt., Negm MS; Department of Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt., Ahmed JA; Department of Medical Parasitology, Faculty of Medicine, Cairo University, Al-Saray St., El Manial, Cairo, 11956 Egypt.
Jazyk: angličtina
Zdroj: Journal of parasitic diseases : official organ of the Indian Society for Parasitology [J Parasit Dis] 2022 Sep; Vol. 46 (3), pp. 704-713. Date of Electronic Publication: 2022 Apr 25.
DOI: 10.1007/s12639-022-01489-z
Abstrakt: Giardia lamblia is one of the most common protozoal parasites in humans, and a major cause of diarrheal illness. Treatment of giardiasis relies on metronidazole (MTZ) and other nitroimidazoles which exhibit some limitations, including variable treatment efficacy and parasite-drug resistance. In this work, we investigated the therapeutic effects of the commercial products of Allium sativum (A. sativum) and Zingiber officinale (Z. officinale) , alone and in combination with MTZ, on giardiasis in experimentally infected hamsters. Parasitological assessments: cysts count, cysts viability and trophozoites count, and histopathological assessment were performed. Results revealed that the percentage of reduction in cysts number in the A. sativum, Z. officinale, A. sativum/ MTZ, and Z. officinale /MTZ treated groups were of 84.5, 88.9, 82, and 86.1%, respectively, compared to infected non-treated group. While MTZ treated group showed percentage of reduction 79.7%. Regarding the cyst viability, it was reduced by 73.4, 76.9, 64.9, and 70.7%, in the A. sativum, Z. officinale, A. sativum/ MTZ, and Z. officinale /MTZ treated groups respectively, compared to 61.9% in the MTZ treated group. For the trophozoites, the percentage of reduction was 64.1, 60.2, 59.4, and 47.3%, respectively, compared to 38.6% in MTZ treated group. The examination of duodenal sections revealed remarkable improvement in the histopathological changes in the A. sativum, Z. officinale, and the MTZ combination groups. In conclusion, A. sativum and Z. officinale preparations showed higher anti-giardial activity compared to MTZ, with higher reduction in Giardia cyst numbers, viability and trophozoite numbers in the experimentally infected hamsters. Further in vivo trials are recommended using A. sativum and Z. officinale preparations in increasing doses to reach a higher cure rate.
Competing Interests: Conflict of interestThe authors declare that they have no conflict of interests.
(© Indian Society for Parasitology 2022.)
Databáze: MEDLINE
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