Clinical and laboratory evaluation of Turkish children with IgG subclass deficiency.

Autor:	Kocaoğlu M; Dr. Ali Kemal Belviranlı Obstetrics and Children's Hospital, Konya, Turkey. Electronic address: drmersault@gmail.com., Kocaoğlu BE; Department of Family Medicine, Konya City Hospital, Konya, Turkey., Erol Aytekin S; Department of Pediatric Immunology and Allergy, Necmettin Erbakan University Meram Medical Faculty, Konya, Turkey., Keskin DM; Dr. Ali Kemal Belviranlı Obstetrics and Children's Hospital, Konya, Turkey., Güner ŞN; Department of Pediatric Immunology and Allergy, Necmettin Erbakan University Meram Medical Faculty, Konya, Turkey., Keleş S; Department of Pediatric Immunology and Allergy, Necmettin Erbakan University Meram Medical Faculty, Konya, Turkey., Reisli İ; Department of Pediatric Immunology and Allergy, Necmettin Erbakan University Meram Medical Faculty, Konya, Turkey.
Jazyk:	angličtina
Zdroj:	Pediatrics and neonatology [Pediatr Neonatol] 2023 Jan; Vol. 64 (1), pp. 38-45. Date of Electronic Publication: 2022 Aug 24.
DOI:	10.1016/j.pedneo.2022.04.014
Abstrakt:	Background: IgG subclass deficiency is a laboratory diagnosis and becomes important with recurrent infections. This study aimed to examine the demographic, clinical, and laboratory results of pediatric cases with IgG subclass deficiency and to improve the understanding of the clinical significance of IgG subclass deficiency. Methods: In this study, the clinical and laboratory features of 111 pediatric patients, with at least one whose serum IgG subclasses was measured as lower than 2 standard deviation of healthy aged-matched control values, were evaluated. The clinical and laboratory features of the cases with isolated IgG subclass deficiency (Group 1) and those with low serum levels of any of IgG, IgA, and IgM in addition to the IgG subclass deficiency (Group 2) were compared. Results: A total of 55 (49.54%) and 56 (50.45%) patients were included in Groups 1 and 2, respectively. Among our studied cases, 20 (18.1%) had a history of hospitalization in the neonatal period, 61 (54.95%) had at least one hospitalization due to infection, and 55 (49.54%) had a history of recurrent infection. The frequencies of these three conditions were statistically significantly higher in Group 2 (p < 0.05). The frequencies of infections in the last year in Groups 1 and 2 were 4.4 ± 1.2 and 5.4 ± 1.9, respectively (p < 0.05). As a result of recurrent infections, 43.24% (n = 48) of our patients received antibiotic prophylaxis, and 21.62% (n = 24) had immunoglobulin replacement therapy. Furthermore, the numbers of patients who needed these treatments were higher in Group 2 (p < 0.05). Conclusion: In cases with IgG subclass deficiencies, concomitant main-group immunoglobulin deficiencies may increase the number and severity of infections, leading to hospitalizations, antibiotic prophylaxis, and immunoglobulin therapy. More attention should be paid to cases of immunoglobulin main-group deficiencies in the follow-up of these cases. Competing Interests: Declaration of competing interest The authors have declared that they have no conflicts of interest relevant to this article. (Copyright © 2022 Taiwan Pediatric Association. Published by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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