Emodin modulates gut microbial community and triggers intestinal immunity.

Autor: Mabwi HA; Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung, South Korea.; Department of Microbiology, Parasitology, and Biotechnology, College of Veterinary Medicine and Biomedical Sciences, Sokoine University of Agriculture, Morogoro, Tanzania.; SACIDS Foundation for One Health, College of Veterinary Medicine and Biomedical Sciences, Sokoine University of Agriculture, Morogoro, Tanzania.; Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seoul, South Korea., Lee HJ; Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung, South Korea., Hitayezu E; Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung, South Korea., Mauliasari IR; Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung, South Korea., Pan CH; Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung, South Korea.; Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seoul, South Korea., Mwaikono KS; Department of Science and Laboratory Technology, Dar es Salaam Institute of Technology, Dar es Salaam, Tanzania., Komba EVG; SACIDS Foundation for One Health, College of Veterinary Medicine and Biomedical Sciences, Sokoine University of Agriculture, Morogoro, Tanzania., Lee CG; Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung, South Korea.; Division of Bio-Medical Science and Technology, KIST School, University of Science and Technology, Seoul, South Korea., Cha KH; Natural Product Informatics Research Center, Korea Institute of Science and Technology, Gangneung, South Korea.
Jazyk: angličtina
Zdroj: Journal of the science of food and agriculture [J Sci Food Agric] 2023 Feb; Vol. 103 (3), pp. 1273-1282. Date of Electronic Publication: 2022 Sep 26.
DOI: 10.1002/jsfa.12221
Abstrakt: Background: The gut microbiota (GM) plays an important role in human health and is being investigated as a possible target for new therapies. Although there are many studies showing that emodin can improve host health, emodin-GM studies are scarce. Here, the effects of emodin on the GM were investigated in vitro and in vivo.
Results: In vitro single bacteria cultivation showed that emodin stimulated the growth of beneficial bacteria Akkermansia, Clostridium, Roseburia, and Ruminococcus but inhibited major gut enterotypes (Bacteroides and Prevotella). Microbial community analysis from a synthetic gut microbiome model through co-culture indicated the consistent GM change by emodin. Interestingly, emodin stimulated Clostridium and Ruminococcus (which are related to Roseburia and Faecalibacterium) in a mice experiment and induced anti-inflammatory immune cells, which may correlate with its impact on specific gut bacteria.
Conclusion: Emodin (i) showed similar GM changes in monoculture, co-culture, and in an in vivo mice experiment and (ii) simulated regulatory T-cell immune responses in vivo. This suggest that emodin may be used to modulate the GM and improve health. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
(© 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.)
Databáze: MEDLINE
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