| Autor: |
el-Badawi MG, Amer MH, Dahaba NM, Fatani JA, Sabah DM, Mustafa FA |
| Jazyk: |
angličtina |
| Zdroj: |
Chemotherapy [Chemotherapy] 1987; Vol. 33 (4), pp. 278-86. |
| DOI: |
10.1159/000238508 |
| Abstrakt: |
Histological changes were studied in experimental animals following the intraperitoneal administration of high-dose cisplatin with or without high-dose methotrexate and citrovorum factor. There were pronounced renal toxicities with high-dose (10 mg/kg) cisplatin, particularly involving distal tubules with glomerular congestion. However, lower toxicities were noted with reduced dosage of cisplatin (5 mg/kg) and especially if given once as a single bolus injection instead of a 5-day regimen. Renal and hepatic toxicities were marked with concomitant methotrexate administration leading to hemorrhagic diathesis and shorter survival. However, toxicities were relatively reduced when cisplatin was given as a single bolus injection instead of a 5-day divided course. Such information may prove helpful in future planning of combination chemotherapy in patients with malignancies using these two agents. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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