Vitamin D deficiency and vitamin D receptor FokI polymorphism as risk factors for COVID-19.

Autor: Zeidan NMS; Department of Pediatrics, Faculty of Medicine, Cairo University, Giza, Egypt., Lateef HMAE; Department of Pediatrics, Faculty of Medicine, Ain-Shams University, Cairo, Egypt., Selim DM; Department of Pediatrics, Faculty of Medicine, Ain-Shams University, Cairo, Egypt., Razek SA; Department of Pediatrics, Faculty of Medicine, Ain-Shams University, Cairo, Egypt., Abd-Elrehim GAB; Department of Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt., Nashat M; Department of Pediatrics, Faculty of Medicine, Aswan University, Aswan, Egypt., ElGyar N; Department of Pediatrics, Faculty of Medicine, Assuit University, Assuit, Egypt., Waked NM; Department of Pediatrics, Faculty of Medicine, October 6 University, 6th of October City, Egypt., Soliman AA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Elhewala AA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Shehab MMM; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Ibraheem AAA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Shehata H; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Yousif YM; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Akeel NE; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Hashem MIA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Ahmed AA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Emam AA; Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig, Egypt. ahmedemam1111@yahoo.com., Abdelmohsen MM; Department of Pediatrics, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt., Ahmed MF; Department of Pediatrics, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt., Saleh ASE; Department of Otorhinolaryngology, Faculty of Medicine, Benha University, Benha, Egypt., Eltrawy HH; Department of Chest Diseases, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt., Shahin GH; Department of Clinical Pathology, Faculty of Medicine, Cairo University, Giza, Egypt., Nabil RM; Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Hosny TA; Department of Clinical Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Abdelhamed MR; Department of Clinical Pathology, Al-Azhar Faculty of Medicine, Cairo, Egypt., Afify MR; Department of Medical Microbiology and Parasitology, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia., Alharbi MT; Department of Medical Microbiology and Parasitology, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia., Nagshabandi MK; Department of Medical Microbiology and Parasitology, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia., Tarabulsi MK; Department of Medical Microbiology and Parasitology, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia., Osman SF; Department of Radiology, Texas Tech University Health Sciences Center, El Paso, TX, USA., Abd-Elrazek ASM; Department of Radio-Diagnosis, Menoufia University, Shibin Al Kawm, Egypt., Rashad MM; Department of Anesthesia, Faculty of Medicine, Zagazig University, Zagazig, Egypt., El-Gaaly SAA; Department of Internal Medicine, Faculty of Medicine, Ain-Shams University, Cairo, Egypt., Gad SAB; Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Mohamed MY; Department of Psychiatry, Faculty of Medicine, Ain-Shams University, Cairo, Egypt., Abdelkhalek K; Department of Pediatrics, Faculty of Medicine, Cairo University, Giza, Egypt., Yousef AA; Department of Pediatrics, Faculty of Medicine, Helwan University, Helwan, Egypt.
Jazyk: angličtina
Zdroj: Pediatric research [Pediatr Res] 2023 Apr; Vol. 93 (5), pp. 1383-1390. Date of Electronic Publication: 2022 Sep 09.
DOI: 10.1038/s41390-022-02275-6
Abstrakt: Background: Given the sparse data on vitamin D status in pediatric COVID-19, we investigated whether vitamin D deficiency could be a risk factor for susceptibility to COVID-19 in Egyptian children and adolescents. We also investigated whether vitamin D receptor (VDR) FokI polymorphism could be a genetic marker for COVID-19 susceptibility.
Methods: One hundred and eighty patients diagnosed to have COVID-19 and 200 matched control children and adolescents were recruited. Patients were laboratory confirmed as SARS-CoV-2 positive by real-time RT-PCR. All participants were genotyped for VDR Fok1 polymorphism by RT-PCR. Vitamin D status was defined as sufficient for serum 25(OH) D at least 30 ng/mL, insufficient at 21-29 ng/mL, deficient at <20 ng/mL.
Results: Ninety-four patients (52%) had low vitamin D levels with 74 (41%) being deficient and 20 (11%) had vitamin D insufficiency. Vitamin D deficiency was associated with 2.6-fold increased risk for COVID-19 (OR = 2.6; [95% CI 1.96-4.9]; P = 0.002. The FokI FF genotype was significantly more represented in patients compared to control group (OR = 4.05; [95% CI: 1.95-8.55]; P < 0.001).
Conclusions: Vitamin D deficiency and VDR Fok I polymorphism may constitute independent risk factors for susceptibility to COVID-19 in Egyptian children and adolescents.
Impact: Vitamin D deficiency could be a modifiable risk factor for COVID-19 in children and adolescents because of its immune-modulatory action. To our knowledge, ours is the first such study to investigate the VDR Fok I polymorphism in Caucasian children and adolescents with COVID-19. Vitamin D deficiency and the VDR Fok I polymorphism may constitute independent risk factors for susceptibility to COVID-19 in Egyptian children and adolescents. Clinical trials should be urgently conducted to test for causality and to evaluate the efficacy of vitamin D supplementation for prophylaxis and treatment of COVID-19 taking into account the VDR polymorphisms.
(© 2022. The Author(s).)
Databáze: MEDLINE
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