Synergistic toxicity of ethanol and 2,4-dichlorophenoxyacetic acid enhances oxidant status, DNA damage, inflammation, and apoptosis in rats.

Autor: Ince S; Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Afyon Kocatepe University, Afyonkarahisar, Turkey. incesinan@gmail.com., Demirel HH; Bayat Vocational School, Afyon Kocatepe University, Afyonkarahisar, Turkey., Zemheri-Navruz F; Faculty of Science, Department of Molecular Biology and Genetics, Bartın University, Bartın, Turkey., Arslan-Acaroz D; Faculty of Veterinary Medicine, Department of Biochemistry, Afyon Kocatepe University, Afyonkarahisar, Turkey., Kucukkurt I; Faculty of Veterinary Medicine, Department of Biochemistry, Afyon Kocatepe University, Afyonkarahisar, Turkey., Acaroz U; Faculty of Veterinary Medicine, Department of Food Hygiene and Technology, Afyon Kocatepe University, Afyonkarahisar, Turkey., Tureyen A; Department of Gastroenterology, Ministry of Health Eskisehir City Hospital, Eskisehir, Turkey., Demirkapi EN; Faculty of Veterinary Medicine, Department of Physiology, Afyon Kocatepe University, Afyonkarahisar, Turkey.
Jazyk: angličtina
Zdroj: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2023 Jan; Vol. 30 (4), pp. 10710-10723. Date of Electronic Publication: 2022 Sep 09.
DOI: 10.1007/s11356-022-22964-3
Abstrakt: Clarifying the interactions between substances as a result of exposure to multiple xenobiotics and determining the impacts on health are important from the toxicological point of view. Therefore, the aim of the study was to investigate the synergistic toxic effects of ethanol and 2,4-dichlorophenoxyacetic acid (2,4-D) in male albino rats. A total number of 28 Wistar male rats were divided into 4 groups (7/each), and 2,4-D (5 mg/kg) and ethanol (3 g/kg) were administered orally to rats for 60 days, either alone or in combination. Co-administration of ethanol and 2,4-D increased liver functional enzyme levels and lipid peroxidation in blood and tissues while decreased glutathione and antioxidant enzyme activities when compared to individual applications. Furthermore, co-administration of ethanol and 2,4-D caused DNA damage as well as the increase in apoptotic and proinflammatory cytokine gene expressions. Furthermore, histopathological examination of the tissues especially liver and kidney revealed that these two substances induced more serious damage. In conclusion, co-administration of ethanol and 2,4-D resulted in strong toxic effects on tissues (especially liver) with a synergistic interaction and give rise to serious toxicological drawbacks.
(© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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