Inferring the initiation and development of myeloproliferative neoplasms.

Autor: Hermange G; Laboratory of Mathematics and Informatics (MICS), Université Paris-Saclay, CentraleSupélec, Gif-sur-Yvette, 91190 France., Rakotonirainy A; Laboratory of Mathematics and Informatics (MICS), Université Paris-Saclay, CentraleSupélec, Gif-sur-Yvette, 91190 France., Bentriou M; Laboratory of Mathematics and Informatics (MICS), Université Paris-Saclay, CentraleSupélec, Gif-sur-Yvette, 91190 France., Tisserand A; INSERM U1287 (INSERM, Gustave Roussy, Université Paris-Saclay), Villejuif, 94800 France.; Gustave Roussy, Villejuif, 94800 France.; Université Paris-Cité, Paris, 75013 France., El-Khoury M; INSERM U1287 (INSERM, Gustave Roussy, Université Paris-Saclay), Villejuif, 94800 France.; Gustave Roussy, Villejuif, 94800 France.; Université Paris-Cité, Paris, 75013 France., Girodon F; Laboratoire d'Hématologie, CHU Dijon, Dijon, 21000 France.; INSERM, UMR866, Centre de Recherche, Dijon, 21000 France., Marzac C; INSERM U1287 (INSERM, Gustave Roussy, Université Paris-Saclay), Villejuif, 94800 France.; Gustave Roussy, Villejuif, 94800 France.; Université Paris-Saclay, Villejuif, 94800 France.; Laboratoire d'Immuno-Hématologie, Gustave Roussy, Villejuif, 94800 France., Vainchenker W; INSERM U1287 (INSERM, Gustave Roussy, Université Paris-Saclay), Villejuif, 94800 France.; Gustave Roussy, Villejuif, 94800 France.; Université Paris-Saclay, Villejuif, 94800 France., Plo I; INSERM U1287 (INSERM, Gustave Roussy, Université Paris-Saclay), Villejuif, 94800 France.; Gustave Roussy, Villejuif, 94800 France.; Université Paris-Saclay, Villejuif, 94800 France., Cournède PH; Laboratory of Mathematics and Informatics (MICS), Université Paris-Saclay, CentraleSupélec, Gif-sur-Yvette, 91190 France.
Jazyk: angličtina
Zdroj: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Sep 13; Vol. 119 (37), pp. e2120374119. Date of Electronic Publication: 2022 Sep 09.
DOI: 10.1073/pnas.2120374119
Abstrakt: The developmental history of blood cancer begins with mutation acquisition and the resulting malignant clone expansion. The two most prevalent driver mutations found in myeloproliferative neoplasms- JAK2 V617F and CALR m -occur in hematopoietic stem cells, which are highly complex to observe in vivo. To circumvent this difficulty, we propose a method relying on mathematical modeling and statistical inference to determine disease initiation and dynamics. Our findings suggest that CALR m mutations tend to occur later in life than JAK2 V617F . Our results confirm the higher proliferative advantage of the CALR m malignant clone compared to JAK2 V617F . Furthermore, we illustrate how mathematical modeling and Bayesian inference can be used for setting up early screening strategies.
Databáze: MEDLINE
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