[The role of systemic ozone therapy in the rehabilitation of patients after COVID-19].

Autor:	Tsvetkova AV; Sechenov First Moscow State Medical University, Moscow, Russia.; Group of companies «MEDSI», Otradnoe, Russia., Koneva ES; Sechenov First Moscow State Medical University, Moscow, Russia.; Group of companies «MEDSI», Otradnoe, Russia., Kostenko AA; Sechenov First Moscow State Medical University, Moscow, Russia., Bisheva DR; Sechenov First Moscow State Medical University, Moscow, Russia., Sidyakina IV; Group of companies «MEDSI», Otradnoe, Russia., Konev SM; Sechenov First Moscow State Medical University, Moscow, Russia.; Group of companies «MEDSI», Otradnoe, Russia., Zhumanova EN; Group of companies «MEDSI», Otradnoe, Russia., Illarionov VE; Petrovsky National Research Centre of Surgery, Moscow, Russia., Shestakov AV; Petrovsky National Research Centre of Surgery, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury [Vopr Kurortol Fizioter Lech Fiz Kult] 2022; Vol. 99 (4. Vyp. 2), pp. 22-29.
DOI:	10.17116/kurort20229904222
Abstrakt:	Objective: To evaluate the effectiveness and safety of ozone therapy in rehabilitation of patients with previous COVID-19. Material and Methods: A randomized controlled clinical trial included 51 patients aged 29 - 78 years with SARS-CoV-2 pneumonia (J12.8). Patients were divided into 3 comparable groups depending on the complex of rehabilitation. In the first (control) group ( n =17), a 10-day course included daily breathing exercises and physiotherapy for the lungs (drug electrophoresis and low-frequency magnetotherapy). In the second (main) group ( n =18), rehabilitation was combined with daily intravenous infusions of ozonized saline with ozone concentration of 2.0 mg/l within 5 days with subsequent standard rehabilitation. In the third group ( n =16), patients received 5 ozone therapy procedures every other day. To determine the effectiveness and safety of systemic ozone therapy in rehabilitation of patients with previous COVID-19, we analyzed oxygen saturation, laboratory data (D-dimer and C-reactive protein), need for oxygen support before and after rehabilitation course. Complaints and quality of life throughout the rehabilitation program were assessed using the EQ-5D questionnaire. Results: All patients had positive changes of all parameters. There were no adverse reactions throughout the rehabilitation program and 2 months later. We observed higher effectiveness of rehabilitation with systemic ozone therapy. Moreover, daily ozone therapy had a better effect on laboratory parameters compared to ozone therapy every other day. Conclusion: Ozone therapy is safe and effective in complex rehabilitation of patients with previous COVID-19. Further studies of large samples are needed to determine indications and appropriate criteria for this rehabilitation program.
Databáze:	MEDLINE
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