Upgrading Carbazolyl-Derived Phosphine Ligands Using Rh I -Catalyzed P III -Directed C-H Bond Alkylation for Catalytic CO 2 -Fixation Reactions.
| Autor: | Rzayev J; Univ Rennes, CNRS, ISCR UMR 6226, F-35000 Rennes, France., Zhang Z; Univ Rennes, CNRS, ISCR UMR 6226, F-35000 Rennes, France., Durand N; Univ Rennes, CNRS, ISCR UMR 6226, F-35000 Rennes, France., Soulé JF; Univ Rennes, CNRS, ISCR UMR 6226, F-35000 Rennes, France. |
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| Jazyk: | angličtina |
| Zdroj: | Organic letters [Org Lett] 2022 Sep 23; Vol. 24 (37), pp. 6755-6760. Date of Electronic Publication: 2022 Sep 09. |
| DOI: | 10.1021/acs.orglett.2c02514 |
| Abstrakt: | We report an Rh(I)-catalyzed C-H bond alkylation of PhenCarPhos [ N -(2-(diphenylphosphaneyl)phenyl)carbazole] and some congener phosphine ligands with alkenes. The C-H bond functionalization occurred exclusively at the C1 position of the carbazolyl unit because the trivalent phosphine acts as a directing group. This protocol provides straightforward access to a large library of C1-alkyl substituted PhenCarPhos, which outperformed common commercial or unfunctionalized phosphines and their precursors in the Pd-catalyzed carbon dioxide-fixation reactions with propargylic amines. |
| Databáze: | MEDLINE |
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