QT and Tpeak-Tend interval variability: Predictive electrical markers of hospital stay length and mortality in acute decompensated heart failure. Preliminary data.

Autor: Piccirillo G; Department of Clinical and Internal Medicine, Anesthesiology and Cardiovascular Sciences, Policlinico Umberto I, 'Sapienza' University of Rome, Rome, Italy., Moscucci F; Department of Clinical and Internal Medicine, Anesthesiology and Cardiovascular Sciences, Policlinico Umberto I, 'Sapienza' University of Rome, Rome, Italy., Carnovale M; Department of Clinical and Internal Medicine, Anesthesiology and Cardiovascular Sciences, Policlinico Umberto I, 'Sapienza' University of Rome, Rome, Italy., Bertani G; Department of Clinical and Internal Medicine, Anesthesiology and Cardiovascular Sciences, Policlinico Umberto I, 'Sapienza' University of Rome, Rome, Italy., Lospinuso I; Department of Clinical and Internal Medicine, Anesthesiology and Cardiovascular Sciences, Policlinico Umberto I, 'Sapienza' University of Rome, Rome, Italy., Di Diego I; Department of Clinical and Internal Medicine, Anesthesiology and Cardiovascular Sciences, Policlinico Umberto I, 'Sapienza' University of Rome, Rome, Italy., Corrao A; Department of Clinical and Internal Medicine, Anesthesiology and Cardiovascular Sciences, Policlinico Umberto I, 'Sapienza' University of Rome, Rome, Italy., Sabatino T; Department of Clinical and Internal Medicine, Anesthesiology and Cardiovascular Sciences, Policlinico Umberto I, 'Sapienza' University of Rome, Rome, Italy., Zaccagnini G; Department of Clinical and Internal Medicine, Anesthesiology and Cardiovascular Sciences, Policlinico Umberto I, 'Sapienza' University of Rome, Rome, Italy., Crapanzano D; Department of Clinical and Internal Medicine, Anesthesiology and Cardiovascular Sciences, Policlinico Umberto I, 'Sapienza' University of Rome, Rome, Italy., Rossi P; Cardiology Division, Arrhythmology Unit, S. Giovanni Calibita, Isola Tiberina, Rome, Italy., Magrì D; Department of Clinical and Molecular Medicine, S. Andrea Hospital, 'Sapienza' University of Rome, Rome, Italy.
Jazyk: angličtina
Zdroj: Clinical cardiology [Clin Cardiol] 2022 Dec; Vol. 45 (12), pp. 1192-1198. Date of Electronic Publication: 2022 Sep 09.
DOI: 10.1002/clc.23888
Abstrakt: Background: As previously reported, an increased repolarization temporal imbalance induces a higher risk of total/cardiovascular mortality.
Hypothesis: The aim of this study was to assess if the electrocardiographic short period markers of repolarization temporal dispersion could be predictive of the hospital stay length and mortality in patients with acutely decompensated chronic heart failure (CHF).
Method: Mean, standard deviation (SD), and normalized variance (VN) of QT (QT) and Tpeak-Tend (Te) were obtained on 5-min ECG recording in 139 patients hospitalized for acutely decompensated CHF, subgrouping the patients for hospital length of stay (LoS): less or equal 1 week (≤1 W) and those with more than 1 week (>1 W).
Results: We observed an increase of short-period repolarization variables (TeSD and TeVN, p < .05), a decrease of blood pressure (p < .05), lower ejection fraction (p < .05), and higher plasma level of biomarkers (NT-proBNP, p < .001; Troponin, p < .05) in >1 W LoS subjects. 30-day deceased subjects reported significantly higher levels of QTSD (p < .05), Te mean (p < .001), TeSD (p < .05), QTVN (p < .05) in comparison to the survivors. Multivariable Cox regression analysis reported that TeVN was a risk factor for longer hospital stay (hazard ratio: 1.04, 95% confidence limit: 1.01-1.08, p < .05); whereas, a longer Te mean was associated with higher mortality risk (hazard ratio: 1.02, 95% confidence limit: 1.01-1.03, p < .05).
Conclusion: A longer hospital stay is considered a clinical surrogate of CHF severity, we confirmed this finding. Therefore, these electrical and simple parameters could be used as noninvasive, transmissible, inexpensive markers of CHF severity and mortality.
(© 2022 The Authors. Clinical Cardiology published by Wiley Periodicals, LLC.)
Databáze: MEDLINE
Externí odkaz: