Magnetically propelled chained nanocomposites for biologically relevant media exploration.

Autor: Ramos-Docampo MA; Departamento de Física Aplicada, Universidade de Vigo, 36310 Vigo, Spain; CINBIO, Universidade de Vigo, 36310 Vigo, Spain., Hurtado P; Roche-Chus Joint Unit, Translational Medical Oncology Group, Oncomet, Health Research Institute of Santiago de Compostela, 15706 Santiago de Compostela, Spain., Dávila-Ibáñez AB; Roche-Chus Joint Unit, Translational Medical Oncology Group, Oncomet, Health Research Institute of Santiago de Compostela, 15706 Santiago de Compostela, Spain., Piñeiro R; Roche-Chus Joint Unit, Translational Medical Oncology Group, Oncomet, Health Research Institute of Santiago de Compostela, 15706 Santiago de Compostela, Spain., Fanarraga ML; Nanomedicine Group, Universidad de Cantabria-IDIVAL, 39011 Santander, Spain., Salgueiriño V; Departamento de Física Aplicada, Universidade de Vigo, 36310 Vigo, Spain; CINBIO, Universidade de Vigo, 36310 Vigo, Spain. Electronic address: vsalgue@uvigo.es.
Jazyk: angličtina
Zdroj: Journal of colloid and interface science [J Colloid Interface Sci] 2023 Jan; Vol. 629 (Pt A), pp. 287-296. Date of Electronic Publication: 2022 Aug 28.
DOI: 10.1016/j.jcis.2022.08.154
Abstrakt: Elongated nanostructures to be remotely and magnetically propelled in biologically relevant media, have gained attention as offering themselves as effective tools or carriers in theragnostics applications. However, the magnetic actuation associated remains challenging due to the lack of mechanical information in the media of interest, taking into account biophysical or biomedical purposes. In this study, we detail the magnetic actuation of magnetically propelled chained nanocomposites considering their dynamics, in which their velocity can be modulated in terms of the viscosity of the medium considered, given a magnetic field gradient. Simpler cases of distilled water, a water/glycerol mixture and a fluid made of cell extracts (imitating the cytosol of cells) of known viscosity are the basis experiments for the study of more complex media inside HeLa cells, murine NIH-3T3 fibroblasts and zebrafish larvae, offering the mechanical information required. The experimental results indicate that the magnetically propelled performance of the chained nanostructures can be precisely controlled in potentially changing scenarios, where drug and heat delivery, magnetic separation, or microfluidic technologies are demanded, using a magnetic field gradient and providing good estimations of the dynamical parameters involved.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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