Neuropathology of the Basal Ganglia in SNCA Transgenic Rat Model of Parkinson's Disease: Involvement of Parvalbuminergic Interneurons and Glial-Derived Neurotropic Factor.

Autor: Paldino E; Laboratory of Neuroanatomy, Fondazione Santa Lucia IRCCS, 00143 Rome, Italy.; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy., D'angelo V; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy., Massaro Cenere M; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.; Department of Experimental Neuroscience, Fondazione Santa Lucia IRCCS, 00143 Rome, Italy., Guatteo E; Department of Experimental Neuroscience, Fondazione Santa Lucia IRCCS, 00143 Rome, Italy.; Department of Motor Science and Wellness, Parthenope University, 80143 Naples, Italy., Barattucci S; Laboratory of Neuroanatomy, Fondazione Santa Lucia IRCCS, 00143 Rome, Italy., Migliorato G; Laboratory of Neuroanatomy, Fondazione Santa Lucia IRCCS, 00143 Rome, Italy., Berretta N; Department of Experimental Neuroscience, Fondazione Santa Lucia IRCCS, 00143 Rome, Italy., Riess O; Institute of Medical Genetics and Applied Genomics, University of Tübingen, 72076 Tübingen, Germany., Sancesario G; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy., Mercuri NB; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.; Department of Experimental Neuroscience, Fondazione Santa Lucia IRCCS, 00143 Rome, Italy., Fusco FR; Laboratory of Neuroanatomy, Fondazione Santa Lucia IRCCS, 00143 Rome, Italy.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2022 Sep 04; Vol. 23 (17). Date of Electronic Publication: 2022 Sep 04.
DOI: 10.3390/ijms231710126
Abstrakt: Parkinson's disease (PD) is a neurodegenerative disease characterized by the accumulation of alpha-synuclein, encoded by the SNCA gene. The main neuropathological hallmark of PD is the degeneration of dopaminergic neurons leading to striatal dopamine depletion. Trophic support by a neurotrophin called glial-derived neurotrophic factor (GDNF) is also lacking in PD. We performed immunohistochemical studies to investigate neuropathological changes in the basal ganglia of a rat transgenic model of PD overexpressing alfa-synuclein. We observed that neuronal loss also occurs in the dorsolateral part of the striatum in the advanced stages of the disease. Moreover, along with the degeneration of the medium spiny projection neurons, we found a dramatic loss of parvalbumin interneurons. A marked decrease in GDNF, which is produced by parvalbumin interneurons, was observed in the striatum and in the substantia nigra of these animals. This confirmed the involvement of the striatum in the pathophysiology of PD and the importance of GDNF in maintaining the health of the substantia nigra.
Databáze: MEDLINE
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