The orphan receptor GPR88 controls impulsivity and is a risk factor for Attention-Deficit/Hyperactivity Disorder.

Autor: Ben Hamida S; Douglas Mental Health University Institute, Montreal, QC, Canada.; Department of Psychiatry, McGill University, Montreal, QC, Canada.; INSERM UMR 1247-Research Group on Alcohol & Pharmacodependences (GRAP), Université de Picardie Jules Verne, Amiens, France., Sengupta SM; Douglas Mental Health University Institute, Montreal, QC, Canada.; Department of Psychiatry, McGill University, Montreal, QC, Canada.; AIMH (Artificial Intelligence for Mental Health) Inc., Montreal, QC, Canada., Clarke E; Douglas Mental Health University Institute, Montreal, QC, Canada.; Department of Psychiatry, McGill University, Montreal, QC, Canada., McNicholas M; Douglas Mental Health University Institute, Montreal, QC, Canada.; Department of Psychiatry, McGill University, Montreal, QC, Canada., Moroncini E; Douglas Mental Health University Institute, Montreal, QC, Canada.; Department of Psychiatry, McGill University, Montreal, QC, Canada., Darcq E; Douglas Mental Health University Institute, Montreal, QC, Canada.; Department of Psychiatry, McGill University, Montreal, QC, Canada.; INSERM U1114, Département de Psychiatrie, Université de Strasbourg, Strasbourg, France., Ter-Stepanian M; Department of Educational and Counselling Psychology, McGill University Montreal, Montreal, QC, Canada.; Department de Psychoéducation, Université de Sherbrooke, Sherbrooke, QC, Canada., Fortier MÈ; Douglas Mental Health University Institute, Montreal, QC, Canada., Grizenko N; Douglas Mental Health University Institute, Montreal, QC, Canada.; Department of Psychiatry, McGill University, Montreal, QC, Canada., Joober R; Douglas Mental Health University Institute, Montreal, QC, Canada.; Department of Psychiatry, McGill University, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada., Kieffer BL; Douglas Mental Health University Institute, Montreal, QC, Canada. brigitte.kieffer@unistra.fr.; Department of Psychiatry, McGill University, Montreal, QC, Canada. brigitte.kieffer@unistra.fr.; INSERM U1114, Département de Psychiatrie, Université de Strasbourg, Strasbourg, France. brigitte.kieffer@unistra.fr.
Jazyk: angličtina
Zdroj: Molecular psychiatry [Mol Psychiatry] 2022 Nov; Vol. 27 (11), pp. 4662-4672. Date of Electronic Publication: 2022 Sep 08.
DOI: 10.1038/s41380-022-01738-w
Abstrakt: The neural orphan G protein coupled receptor GPR88 is predominant in the striatum and cortex of both rodents and humans, and considered a potential target for brain disorders. Previous studies have shown multiple behavioral phenotypes in Gpr88 knockout mice, and human genetic studies have reported association with psychosis. Here we tested the possibility that GPR88 contributes to Attention Deficit Hyperactivity Disorder (ADHD). In the mouse, we tested Gpr88 knockout mice in three behavioral paradigms, best translatable between rodents and humans, and found higher motor impulsivity and reduced attention together with the reported hyperactivity. Atomoxetine, a typical ADHD drug, reduced impulsivity in mutant mice. Conditional Gpr88 knockout mice in either D1R-type or D2R-type medium spiny neurons revealed distinct implications of the two receptor populations in waiting and stopping impulsivity. Thus, animal data demonstrate that deficient GPR88 activity causally promotes ADHD-like behaviors, and identify circuit mechanisms underlying GPR88-regulated impulsivity. In humans, we performed a family-based genetic study including 567 nuclear families with DSM-IV diagnosis of ADHD. There was a minor association for SNP rs2036212 with diagnosis, treatment response and cognition. A stronger association was found for SNP rs2809817 upon patient stratification, suggesting that the T allele is a risk factor when prenatal stress is involved. Human data therefore identify GPR88 variants associated with the disease, and highlight a potential role of life trajectories to modulate GPR88 function. Overall, animal and human data concur to suggest that GPR88 signaling should be considered a key factor for diagnostic and treatment of ADHD.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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