Acute Interstitial Pneumonia (Hamman-Rich Syndrome) in Lung Transplantation: A Case Series.

Autor: Shepherd HM; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO., Terada Y; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO., Takahashi T; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO. Electronic address: tsuyoshi.takahashi@wustl.edu., Pasque MK; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO., Kulkarni HS; Division of Pulmonary & Critical Care, Washington University School of Medicine, St. Louis, MO., Guillamet RV; Division of Pulmonary & Critical Care, Washington University School of Medicine, St. Louis, MO., Witt CA; Division of Pulmonary & Critical Care, Washington University School of Medicine, St. Louis, MO., Nava RG; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO., Puri V; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO., Kreisel D; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO., Patterson GA; Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO., Hachem RR; Division of Pulmonary & Critical Care, Washington University School of Medicine, St. Louis, MO.
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2022 Oct; Vol. 54 (8), pp. 2313-2316. Date of Electronic Publication: 2022 Sep 06.
DOI: 10.1016/j.transproceed.2022.07.010
Abstrakt: Background: Acute interstitial pneumonia (AIP), also known as Hamman-Rich syndrome, is a rare and rapidly progressive idiopathic interstitial lung disease with a high mortality rate. Treatment is limited to supportive care and empirical high-dose steroids; however, outcomes are generally poor. There are few reports of lung transplantation (LTx) in patients with AIP.
Methods: We retrospectively identified patients with AIP among those who underwent LTx at our center between January 2008 and December 2020.
Results: During the study period, 4 patients with AIP underwent bilateral LTx: 3 men and 1 woman, between 30 and 57 years of age. The lung allocation score ranged between 71 and 89. Of the 4 patients, 2 needed extracorporeal membrane oxygenation and mechanical ventilation (MV) and 1 needed MV preoperatively. Time of onset to transplant ranged from 1 to 3 months. None of the patients had primary graft dysfunction after LTx; 2 had acute cellular rejection and 1 had chronic lung allograft dysfunction. The 4 patients are alive with survival ranging between 1 and 12 years after LTx.
Conclusion: AIP should be considered in patients with acute respiratory failure without a clear etiology. Our study showed that LTx led to good outcomes and should be considered as a treatment option in appropriate candidates.
Competing Interests: Disclosures HMS and YT share first co-authorship. The authors declare that we have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: