Reprogramming the topology of the nociceptive circuit in C. elegans reshapes sexual behavior.

Autor: Pechuk V; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel., Goldman G; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel., Salzberg Y; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel., Chaubey AH; Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA., Bola RA; Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA., Hoffman JR; Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA., Endreson ML; Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA., Miller RM; Department of Brain and Cognitive Sciences, University of Rochester, Rochester, NY 14627, USA., Reger NJ; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA., Portman DS; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14642, USA., Ferkey DM; Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA., Schneidman E; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: elad.schneidman@weizmann.ac.il., Oren-Suissa M; Department of Brain Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: meital.oren@weizmann.ac.il.
Jazyk: angličtina
Zdroj: Current biology : CB [Curr Biol] 2022 Oct 24; Vol. 32 (20), pp. 4372-4385.e7. Date of Electronic Publication: 2022 Sep 07.
DOI: 10.1016/j.cub.2022.08.038
Abstrakt: The effect of the detailed connectivity of a neural circuit on its function and the resulting behavior of the organism is a key question in many neural systems. Here, we study the circuit for nociception in C. elegans, which is composed of the same neurons in the two sexes that are wired differently. We show that the nociceptive sensory neurons respond similarly in the two sexes, yet the animals display sexually dimorphic behaviors to the same aversive stimuli. To uncover the role of the downstream network topology in shaping behavior, we learn and simulate network models that replicate the observed dimorphic behaviors and use them to predict simple network rewirings that would switch behavior between the sexes. We then show experimentally that these subtle synaptic rewirings indeed flip behavior. Interestingly, when presented with aversive cues, rewired males were compromised in finding mating partners, suggesting that network topologies that enable efficient avoidance of noxious cues have a reproductive "cost." Our results present a deconstruction of the design of a neural circuit that controls sexual behavior and how to reprogram it.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE