Modified ent -Abietane Diterpenoids from the Leaves of Suregada zanzibariensis .

Autor: Kalenga TM; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania.; Department of Chemistry, College of Education, Mwalimu Julius K. Nyerere University of Agriculture and Technology, P.O. Box 976, Butiama, Tanzania., Mollel JT; Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.; Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, S-413 46 Gothenburg, Sweden., Said J; Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, S-413 46 Gothenburg, Sweden., Orthaber A; Department of Chemistry - Ångström, Uppsala University, SE-751 20 Uppsala, Sweden., Ward JS; University of Jyvaskyla, Department of Chemistry, 40014 Jyväskylä, Finland., Atilaw Y; Department of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden., Umereweneza D; Department of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden.; Department of Chemistry, College of Science and Technology, University of Rwanda, P.O Box 3900, Kigali, Rwanda., Ndoile MM; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania., Munissi JJE; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania., Rissanen K; University of Jyvaskyla, Department of Chemistry, 40014 Jyväskylä, Finland., Trybala E; Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, S-413 46 Gothenburg, Sweden., Bergström T; Department of Infectious Diseases/Virology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, S-413 46 Gothenburg, Sweden., Nyandoro SS; Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania., Erdelyi M; Department of Chemistry - BMC, Uppsala University, SE-751 23 Uppsala, Sweden.
Jazyk: angličtina
Zdroj: Journal of natural products [J Nat Prod] 2022 Sep 23; Vol. 85 (9), pp. 2135-2141. Date of Electronic Publication: 2022 Sep 08.
DOI: 10.1021/acs.jnatprod.2c00147
Abstrakt: The leaf extract of Suregada zanzibariensis gave two new modified ent -abietane diterpenoids, zanzibariolides A ( 1 ) and B ( 2 ), and two known triterpenoids, simiarenol ( 3 ) and β-amyrin ( 4 ). The structures of the isolated compounds were elucidated based on NMR and MS data analysis. Single-crystal X-ray diffraction was used to establish the absolute configurations of compounds 1 and 2 . The crude leaf extract inhibited the infectivity of herpes simplex virus 2 (HSV-2, IC 50 11.5 μg/mL) and showed toxicity on African green monkey kidney (GMK AH1) cells at CC 50 52 μg/mL. The isolated compounds 1 - 3 showed no anti-HSV-2 activity and exhibited insignificant toxicity against GMK AH1 cells at ≥100 μM.
Databáze: MEDLINE