Association between obesity and hospitalization in mild COVID-19 adult outpatients in Brazil: a prospective cohort study.

Autor:	Sartor ITS; Responsabilidade Social, Hospital Moinhos de Vento, Porto Alegre, RS, Brasil, ivaine.sartor@hmv.org.br., de David CN; Responsabilidade Social, Hospital Moinhos de Vento, Porto Alegre, RS, Brasil., Telo GH; Faculdade de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brasil., Zavaglia GO; Responsabilidade Social, Hospital Moinhos de Vento, Porto Alegre, RS, Brasil., Fernandes IR; Responsabilidade Social, Hospital Moinhos de Vento, Porto Alegre, RS, Brasil., Kern LB; Responsabilidade Social, Hospital Moinhos de Vento, Porto Alegre, RS, Brasil., Polese-Bonatto M; Responsabilidade Social, Hospital Moinhos de Vento, Porto Alegre, RS, Brasil., Azevedo TR; Responsabilidade Social, Hospital Moinhos de Vento, Porto Alegre, RS, Brasil., Santos AP; Responsabilidade Social, Hospital Moinhos de Vento, Porto Alegre, RS, Brasil., de Almeida WAF; Coordenação Geral, Programa Nacional de Imunizações, Ministério da Saúde do Brasil, Brasília, DF, Brasil., Porto VBG; Coordenação Geral, Programa Nacional de Imunizações, Ministério da Saúde do Brasil, Brasília, DF, Brasil., Varela FH; Responsabilidade Social, Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.; Faculdade de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brasil., Scotta MC; Responsabilidade Social, Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.; Faculdade de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brasil., Rosa RG; Responsabilidade Social, Hospital Moinhos de Vento, Porto Alegre, RS, Brasil., Stein RT; Responsabilidade Social, Hospital Moinhos de Vento, Porto Alegre, RS, Brasil.; Faculdade de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Jazyk:	angličtina
Zdroj:	Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2022 Sept 08; Vol. 66 (4), pp. 512-521.
DOI:	10.20945/2359-3997000000486
Abstrakt:	Objective: To evaluate the association between obesity and hospitalization in mild COVID-19 adult outpatients in Brazil. Methods: Adults with signs and symptoms suggestive of acute SARS-CoV-2 infection who sought treatment in two hospital (public and private) emergency departments were prospectively enrolled. Patients with confirmed COVID-19 at inclusion were followed by phone calls at days D7, D14 and D28. Multivariable logistic regression models were employed to explore the association between obesity and other potential predictors for hospitalization. Results: A total of 1,050 participants were screened, and 297 completed the 28-day follow-up and were diagnosed with COVID-19 by RT-PCR. The median age was 37.2 (IQR 29.7-44.6) years, and 179 (60.0%) were female. The duration of symptoms was 3.0 (IQR 2.0-5.0) days, and 10.0 (IQR 8.0-12.0) was the median number of symptoms at inclusion. Ninety-five (32.0%) individuals had obesity, and 233 (78.5%) had no previous medical conditions. Twenty-three participants (7.7%) required hospitalization during the follow-up period. After adjusting, obesity (BMI ≥ 30.0 kg/m 2 ) (OR = 2.69, 95% CI 1.63-4.83, P < 0.001) and older age (OR = 1.05, 95% CI 1.01-1.09, P < 0.001) were significantly associated with higher risks of hospitalization. Conclusion: Obesity, followed by aging, was the main factor associated with hospital admission for COVID-19 in a young population in a low-middle income country. Our findings highlighted the need to promote additional protection for individuals with obesity, such as vaccination, and to encourage lifestyle changes.
Databáze:	MEDLINE
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