| Autor: |
Floroni E; Discipline of Management, Legislation and Communication in Dental Medicine, Discipline of Ergonomics and Oral Diagnosis, Faculty of Dental Medicine, Victor Babeş University of Medicine and Pharmacy, Timişoara, Romania; ramona.popovici@umft.ro, ioana.talpos-niculescu@umft.ro., Ceauşu AR, Cosoroabă RM, Niculescu Talpoş IC, Popovici RA, Gaje NP, Raica M |
| Jazyk: |
angličtina |
| Zdroj: |
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie [Rom J Morphol Embryol] 2022 Jan-Mar; Vol. 63 (1), pp. 129-135. |
| DOI: |
10.47162/RJME.63.1.13 |
| Abstrakt: |
Breast cancer (BrCa) is the most frequent neoplastic disease in female, with high morbidity and mortality. Most of the researches were focused on tumor cells concerning their natural evolution, molecular profile, and potential response to therapy. Few and uncertain data are available about the tumor microenvironment and its impact on the progression of the disease. Mast cells (MCs) associated to BrCa have been reported many years ago, but their real and specific role in the biology of this disease remained elusive. In the current study, we have investigated the predictive role of MCs from the primary tumor on lymph node metastasis on patients stratified based on the molecular classification. We investigated 156 patients with BrCa, stratified as luminal A, luminal B, human epidermal growth factor receptor 2 (HER2) type, basal-like, and unclassified. MCs were identified with anti-MC tryptase antibody in a double immunohistochemical reaction combined with anti-cluster of differentiation 34 (CD34) antibody. Mast cell density (MCD) was calculated based on the hot-spot method, on three fields with maximum density of MCs in each case. The final result was the arithmetic media that was compared with the molecular profile and lymph node metastases. We found no significant correlation between MCD and the molecular profile of the primary tumor, but we noticed a strong correlation between intratumor MCD and lymph node metastases, regardless of the molecular type. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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