Docosahexaenoic Acid Effect on Prenatal Exposure to Arsenic and Atopic Dermatitis in Mexican Preschoolers.

Autor: Figueroa-Garduño I; Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Morelos, Cuernavaca, México., Escamilla-Núñez C; Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Morelos, Cuernavaca, México. mescamilla@insp.mx., Barraza-Villarreal A; Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Morelos, Cuernavaca, México., Hernández-Cadena L; Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Morelos, Cuernavaca, México., Onofre-Pardo EN; Departamento de Ingeniería en Sistemas Ambientales, Instituto Politécnico Nacional: Escuela Nacional de Ciencias Biológicas, Ciudad de Mexico, México., Romieu I; Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Morelos, Cuernavaca, México.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2023 Jul; Vol. 201 (7), pp. 3152-3161. Date of Electronic Publication: 2022 Sep 08.
DOI: 10.1007/s12011-022-03411-3
Abstrakt: Childhood atopic dermatitis (AD) is a chronic and recurrent health problem that involves multiple factors, particularly immunological and environmental. We evaluated the impact of docosahexaenoic acid (DHA) supplementation on prenatal arsenic exposure on the risk of atopic dermatitis in preschool children as part of the POSGRAD (Prenatal Omega-3 fatty acid Supplements, GRowth, And Development) clinical trial study in the city of Morelos, Mexico. Our study population included 300 healthy mother-child pairs. Of these, 146 were in the placebo group and 154 in the supplement group. Information on family history, health, and other variables was obtained through standardized questionnaires used during follow-up. Prenatal exposure to arsenic concentrations, which appear in maternal urine, was measured by inductively coupled plasma optical emission spectrometry. To assess the effect of prenatal arsenic exposure on AD risk, we ran a generalized estimating equation model for longitudinal data, adjusting for potential confounders, and testing for interaction by omega-3 fatty acid supplementation during pregnancy. The mean and SD (standard deviation) of arsenic concentration during pregnancy was 0.06 mg/L, SD (0.04 mg/L). We found a marginally significant association between prenatal arsenic exposure and AD (OR = 1.12, 95% CI: 0.99, 1.26); however, DHA supplementation during pregnancy modified the effect of arsenic on AD risk (p < 0.05). The results of this study strengthen the evidence that arsenic exposure during pregnancy increases the risk of atopic dermatitis early in life. However, supplementation with omega-e fatty acids during pregnancy could modify this association.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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