Drawn-on-Skin Sensors from Fully Biocompatible Inks toward High-Quality Electrophysiology.

Autor: Patel S; Department of Mechanical Engineering, University of Houston, Houston, TX, 77204, USA., Ershad F; Department of Biomedical Engineering, University of Houston, Houston, TX, 77204, USA., Lee J; Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, 60637, USA., Chacon-Alberty L; Regenerative Medicine Research, Texas Heart Institute, Houston, TX, 77030, USA., Wang Y; Department of Biomedical Engineering, University of Houston, Houston, TX, 77204, USA., Morales-Garza MA; Cardiovascular Surgery Research, Texas Heart Institute, Houston, TX, 77030, USA., Haces-Garcia A; Department of Electrical and Computer Engineering, University of Houston, Houston, TX, 77204, USA., Jang S; Materials Science and Engineering Program, University of Houston, Houston, TX, 77204, USA., Gonzalez L; Department of Biomedical Engineering, University of Houston, Houston, TX, 77204, USA., Contreras L; Department of Biomedical Engineering, University of Houston, Houston, TX, 77204, USA., Agarwal A; Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, 77204, USA., Rao Z; Materials Science and Engineering Program, University of Houston, Houston, TX, 77204, USA., Liu G; Bellaire High School, Bellaire, TX, 77041, USA., Efimov IR; Department of Biomedical Engineering, The George Washington University, Washington, DC, 20052, USA., Zhang YS; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA., Zhao M; Department of Dermatology, University of California Davis, Sacramento, CA, 95816, USA., Isseroff RR; Department of Dermatology, University of California Davis, Sacramento, CA, 95816, USA., Karim A; Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX, 77204, USA., Elgalad A; Cardiovascular Surgery Research, Texas Heart Institute, Houston, TX, 77030, USA., Zhu W; Department of Mechanical Engineering, University of Houston, Houston, TX, 77204, USA.; Department of Engineering Technology, University of Houston, Houston, TX, 77204, USA., Wu X; Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, 60637, USA., Yu C; Department of Mechanical Engineering, University of Houston, Houston, TX, 77204, USA.; Department of Biomedical Engineering, University of Houston, Houston, TX, 77204, USA.; Department of Electrical and Computer Engineering, University of Houston, Houston, TX, 77204, USA.; Materials Science and Engineering Program, University of Houston, Houston, TX, 77204, USA.; Texas Center for Superconductivity, University of Houston, Houston, TX, 77204, USA.
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2022 Sep; Vol. 18 (36), pp. e2107099. Date of Electronic Publication: 2022 Feb 19.
DOI: 10.1002/smll.202107099
Abstrakt: The need to develop wearable devices for personal health monitoring, diagnostics, and therapy has inspired the production of innovative on-demand, customizable technologies. Several of these technologies enable printing of raw electronic materials directly onto biological organs and tissues. However, few of them have been thoroughly investigated for biocompatibility of the raw materials on the cellular, tissue, and organ levels or with different cell types. In addition, highly accurate multiday in vivo monitoring using such on-demand, in situ fabricated devices has yet to be done. Presented herein is the first fully biocompatible, on-skin fabricated electronics for multiple cell types and tissues that can capture electrophysiological signals with high fidelity. While also demonstrating improved mechanical and electrical properties, the drawn-on-skin ink retains its properties under various writing conditions, which minimizes the variation in electrical performance. Furthermore, the drawn-on-skin ink shows excellent biocompatibility with cardiomyocytes, neurons, mice skin tissue, and human skin. The high signal-to-noise ratios of the electrophysiological signals recorded with the DoS sensor over multiple days demonstrate its potential for personalized, long-term, and accurate electrophysiological health monitoring.
(© 2022 Wiley-VCH GmbH.)
Databáze: MEDLINE
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