Fagonia indica attenuates chromium-induced nephrotoxicity via antioxidant and anti-inflammatory activities in mice.

Autor:	Almilaibary A; Faculty of Medicine, Albaha University, Albaha, Saudi Arabia., Abdallah EAA; Faculty of Medicine, Albaha University, Albaha, Saudi Arabia.; Faculty of Medicine, Zagazig University, Egypt., El-Refaei MF; Faculty of Medicine, Albaha University, Albaha, Saudi Arabia.; Genetic Institute, Sadat City University, Egypt.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2022 Aug 27; Vol. 8 (8), pp. e10373. Date of Electronic Publication: 2022 Aug 27 (Print Publication: 2022).
DOI:	10.1016/j.heliyon.2022.e10373
Abstrakt:	Chromium (Cr) is a common environmental pollutant that has wide-ranging toxic manifestations. Fagonia indica ( F. indica ) is an herbal medicine with anti-inflammatory properties and antioxidant activity. This study aims to evaluate the protective role of F. indica (whole plant) in attenuating Cr-induced nephrotoxicity in Swiss mice. Swiss albino mice were divided into five groups (10 mice in each): group I (control); group II ( F. indica -treated); group III (Cr-intoxicated); group IV (Cr- and saline-intoxicated); and group V (Cr-intoxicated and F. indica -treated). Blood samples were drawn after sacrifice for biochemical examinations. Kidney specimens were collected to examine antioxidant activities and conduct histological and immunohistochemical studies for all groups. Mice intoxicated with Cr at 15 mg/kg/b.wt showed a decrease in superoxide dismutase (SOD), glutathione S-transferase (GST), and glutathione peroxidase (GSH-Px) levels compared to the control group, followed by an elevation in the serum IL-6 level. The data revealed severe damage to the renal tubular epithelial cells as well as marked congestion and positive, diffuse, and strong expression of caspase-3 in the dilated tubules. Additionally, the data disclosed an increase in the serum level of blood urea nitrogen (BUN) and creatinine in group III compared with group I. Group V, treated with F. indica at a selected dose of 120 mg/kg/b.wt, showed an improvement in antioxidant activity, attenuation of the IL-6 level, fewer histopathological disturbances, and a statistically significant decrease in the serum level of BUN and creatinine compared with group III. Such changes may be attributed to the antioxidant and anti-inflammatory effects of F. indica . Therefore, our investigation revealed that F. indica effectively protects against Cr-induced nephrotoxicity. Competing Interests: The authors declare no conflict of interest. (© 2022 The Author(s).)
Databáze:	MEDLINE
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