| Autor: |
Wyrwicz AM, Conboy CB, Nichols BG, Ryback KR, Eisele P |
| Jazyk: |
angličtina |
| Zdroj: |
Biochimica et biophysica acta [Biochim Biophys Acta] 1987 Jul 29; Vol. 929 (3), pp. 271-7. |
| DOI: |
10.1016/0167-4889(87)90253-9 |
| Abstrakt: |
Halothane distribution and elimination from rabbit brain was studied in vivo using 19F-NMR spectroscopy. Two exponential decay functions for the anesthetic were observed in the clearance curve. They are assigned to halothane in brain held in two distinct chemical environments characterized by different chemical shifts, and half-lives (25 and 320 min). A nonvolatile halothane metabolite with a half-life of several days was found to be present in rabbit brains. The in vivo results were corroborated by ex vivo experiments on excised brain tissue. Halothane was distributed in all of the major cell subfractions, whereas the metabolite was present predominantly in the cytoplasm. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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