Effects of ceramic additives and bioactive coatings on the degradation of polylactic acid-based bone scaffolds under hydrolytic conditions.

Autor: Donate R; Departamento de Ingeniería Mecánica, Grupo de Investigación en Fabricación Integrada y Avanzada, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain., Monzón M; Departamento de Ingeniería Mecánica, Grupo de Investigación en Fabricación Integrada y Avanzada, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain., Alemán-Domínguez ME; Departamento de Ingeniería Mecánica, Grupo de Investigación en Fabricación Integrada y Avanzada, Universidad de Las Palmas de Gran Canaria, Las Palmas, Spain., Rodríguez-Esparragón F; Unidad de Investigación, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas, Spain.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2023 Feb; Vol. 111 (2), pp. 429-441. Date of Electronic Publication: 2022 Sep 07.
DOI: 10.1002/jbm.b.35162
Abstrakt: Polylactic acid (PLA) has been extensively used for the manufacturing of scaffolds in bone tissue engineering applications. Due to the low hydrophilicity and the acidic degradation process of this biomaterial, different strategies have been proposed to increase the biofunctionality of the support structure. The use of ceramic particles is a generally preferred option to increase the osteoconductivity of the base material, while acting as buffers to maintain the pH level of the surroundings tissues. Surface modification is another approach to overcome the limitations of PLA for tissue engineering applications. In this work, the degradation profile of 3D-printed PLA scaffolds containing beta-tricalcium phosphate (β-TCP) and calcium carbonate (CaCO 3 ) particles has been studied under hydrolytic conditions. Composite samples treated with plasma and coated with Aloe vera extracts were also studied to evaluate the effect of this surface modification method. The characterization of the 3D structures included its morphological, calorimetric and mechanical evaluation. According to the results obtained, the proposed composite scaffolds allowed an adequate maintenance of the pH level of the surrounding medium, with no effects observed on the morphology and mechanical properties of these structures. Hence, these samples showed potential to be further investigated as candidates for bone tissue regeneration.
(© 2022 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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