Glomerular macrophage index (GMI) in kidney transplant biopsies is associated with graft outcome.

Autor: Mölne J; Institute of Biomedicine, Department of Laboratory Medicine, University of Gothenburg, Gothenburg, Sweden.; Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden., Nasic S; Department of Molecular and Clinical Medicine, Institute of Medicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Research and Development Centre, Skaraborg Hospital, Skövde, Sweden., Bröcker V; Institute of Biomedicine, Department of Laboratory Medicine, University of Gothenburg, Gothenburg, Sweden.; Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden., Stegmayr B; Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Felldin M; Department of Transplantation University of Gothenburg, Gothenburg, Sweden., Peters B; Department of Molecular and Clinical Medicine, Institute of Medicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.; Department of Nephrology, Skaraborg Hospital, Skövde, Sweden.
Jazyk: angličtina
Zdroj: Clinical transplantation [Clin Transplant] 2022 Dec; Vol. 36 (12), pp. e14816. Date of Electronic Publication: 2022 Sep 22.
DOI: 10.1111/ctr.14816
Abstrakt: Background: Macrophages in renal transplants have been shown to participate in antibody-mediated rejection and are associated with impaired renal function. We calculated the glomerular macrophage index (GMI) in a large transplant biopsy cohort, studied its quantity in different diagnostic groups, to clarify its possible impact on graft survival.
Methods: GMI, defined as the mean number of macrophages in 10 glomeruli, was prospectively quantified in 1440 renal transplant biopsies over a 10-year period. The main histopathological diagnoses were grouped into eight disease entities, and GMI was compared to normal transplant biopsies as the reference group. The impact of GMI on graft survival was analyzed.
Results: GMI was highest in chronic (mean 9.4) and active (9.7) antibody mediated rejections (ABMR), mixed rejections (7.6), and recurrent or de novo glomerulonephritis (7.5) and differed significantly from normal transplants (1.3) in almost all diagnostic groups. Hazard ratios for graft loss were significantly increased for all biopsies with GMI ≥1.9 compared to GMI < .5 (reference group) in an adjusted Cox regression model and increased with higher GMI levels. Biopsies with GMI ≥ 4.6 had < 60% 10-year graft-survival, compared to > 80% with GMI ≤ 1.8.
Conclusion: GMI levels were predictive of graft loss independent of histological diagnoses and may guide clinicians to decide follow-up and therapy.
(© 2022 The Authors. Clinical Transplantation published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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