| Autor: |
Ben-Zichri S; Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva84105, Israel., Rajendran S; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore632014, India., Bhunia SK; Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore632014, India., Jelinek R; Department of Chemistry, Ben-Gurion University of the Negev, Beer Sheva84105, Israel. |
| Jazyk: |
angličtina |
| Zdroj: |
Bioconjugate chemistry [Bioconjug Chem] 2022 Sep 21; Vol. 33 (9), pp. 1663-1671. Date of Electronic Publication: 2022 Sep 06. |
| DOI: |
10.1021/acs.bioconjchem.2c00282 |
| Abstrakt: |
Resveratrol, a natural polyphenol, exhibits beneficial health properties and has been touted as a potential anti-tumor agent. Here, we demonstrate potent anti-cancer effects of carbon dots (C-dots) synthesized from resveratrol. The mild synthesis conditions retained resveratrol functional moieties upon the carbon dots' (C-dots) surface, an important requisite for achieving specificity toward cancer cells and biological activities. Indeed, the disruptive effects of the resveratrol-C-dot were more pronounced in several cancer cell types compared to normal cells, underscoring targeting capabilities of the C-dots, a pertinent issue for the development of cancer therapeutics. In particular, we observed impairment of mitochondrial functionalities, including intracellular calcium release, inhibition of cytochrome-C oxidase enzyme activity, and mitochondrial membrane perturbation. Furthermore, the resveratrol C-dots were more potent than either resveratrol molecules alone, known anti-cancer polyphenolic agents such as curcumin and triphenylphosphonium, or C-dots prepared from different carbonaceous precursors. This study suggests that resveratrol-synthesized C-dots may have promising therapeutic potential as anti-cancer agents. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
