A cross-sectional study of clinical, dermoscopic, histopathological, and molecular patterns of scalp melanoma in patients with or without androgenetic alopecia.

Autor: Porto AC; Cutaneous Oncology Department, A. C. Camargo Cancer Center, Rua Pires da Mota, 1167, São Paulo, SP, 01529-001, Brazil., Pinto Blumetti T; Cutaneous Oncology Department, A. C. Camargo Cancer Center, Rua Pires da Mota, 1167, São Paulo, SP, 01529-001, Brazil., Calsavara VF; Department of Epidemiology and Statistics, A. C. Camargo Cancer Center, São Paulo, Brazil., Tardin Torrezan G; Genomics and Molecular Biology Group, A. C. Camargo Cancer Center, Rua Taguá, 440, São Paulo, SP, 0508-010, Brazil.; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, A. C. Camargo Cancer Center, Rua Professor Antonio Prudente, 211, São Paulo, Brazil., Andrade de Paula CA; Genomics and Molecular Biology Group, A. C. Camargo Cancer Center, Rua Taguá, 440, São Paulo, SP, 0508-010, Brazil., Lellis R; Department of Pathology, A. C. Camargo Cancer Center, Rua Professor Antonio Prudente, 211, São Paulo, Brazil., Pedreira Duprat Neto J; Cutaneous Oncology Department, A. C. Camargo Cancer Center, Rua Pires da Mota, 1167, São Paulo, SP, 01529-001, Brazil., Carraro DM; Genomics and Molecular Biology Group, A. C. Camargo Cancer Center, Rua Taguá, 440, São Paulo, SP, 0508-010, Brazil.; National Institute of Science and Technology in Oncogenomics and Therapeutic Innovation, A. C. Camargo Cancer Center, Rua Professor Antonio Prudente, 211, São Paulo, Brazil., Casagrande Tavoloni Braga J; Cutaneous Oncology Department, A. C. Camargo Cancer Center, Rua Pires da Mota, 1167, São Paulo, SP, 01529-001, Brazil. jcasagrande.dermato@gmail.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Sep 05; Vol. 12 (1), pp. 15096. Date of Electronic Publication: 2022 Sep 05.
DOI: 10.1038/s41598-022-17108-z
Abstrakt: Scalp melanoma (SM) has a worse prognosis than melanoma in other locations likely because of late diagnosis due to hair coverage, difficulties in interpreting dermoscopy findings, and its unique molecular profile. We aimed to describe the clinical, histopathological, molecular, and dermoscopic patterns of SM and its relation to androgenetic alopecia/elastosis at the tumor site. Through a retrospective cross-sectional study, we identified all SM diagnosed at the A.C.Camargo Cancer Center between 2008 and 2018. In all, 48 SM were analyzed: 45.8% of which exhibited moderate/severe androgenetic alopecia and 54.1% exhibited elastosis. Androgenetic alopecia/elastosis at the site of the SM was associated with older age (p < 0.001), chronic sun damage (p < 0.001), lentigo maligna subtype (p = 0.029), and photodamaged dermoscopic pattern (p < 0.001). Additionally, 41 cases were evaluated with a 14-gene panel: 53.7% displayed mutations and 46.3% were wild-type. BRAF mutations were most common (77%), with BRAF V600K being more frequent (50%) than BRAF V600E (31.2%). The NF1 gene was evaluated in 40 samples, of which 20% exhibited mutations. SM presents differently in areas covered by hair compared to in areas with androgenetic alopecia. Patients without alopecia may have higher Breslow thickness due to late diagnosis because of hair concealment. The high frequency of detrimental mutations can also explain the poor prognosis of SM.
(© 2022. The Author(s).)
Databáze: MEDLINE
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