Comparison of safety and efficacy of silicone hydrogel contact Lens-assisted CXL and accelerated CXL in keratoconus patients with thin corneas.

Autor:	Uysal BS; Department of Ophthalmology, 37511Gazi University Faculty of Medicine, Ankara, Turkey., Ozmen MC; Department of Ophthalmology, 37511Gazi University Faculty of Medicine, Ankara, Turkey., Yuksel M; Department of Ophthalmology, 37511Gazi University Faculty of Medicine, Ankara, Turkey., Aydın B; Department of Ophthalmology, 37511Gazi University Faculty of Medicine, Ankara, Turkey., Bilgihan K; Department of Ophthalmology, 37511Gazi University Faculty of Medicine, Ankara, Turkey.
Jazyk:	angličtina
Zdroj:	European journal of ophthalmology [Eur J Ophthalmol] 2023 Jan; Vol. 33 (1), pp. 44-51. Date of Electronic Publication: 2022 Sep 04.
DOI:	10.1177/11206721221125029
Abstrakt:	Purpose: To evaluate the efficacy and safety of silicone hydrogel contact lens-assisted corneal cross-linking (CL-CXL) and compare 12-month visual and topographic outcomes with accelerated CXL using hypo-osmolar riboflavin (A-CXL) in keratoconus patients with thin corneas (below 400 μm with epithelium). Methods: This retrospective study included 27 eyes of 27 keratoconus patients who underwent CL-CXL (n = 14) or A-CXL (n = 13). Uncorrected and corrected distance visual acuity (UDVA and CDVA) and data obtained from corneal topography were analyzed at baseline and again at 6- and 12-month follow-ups. Corneal demarcation line depth (DLD) was measured at one month, and changes in the corneal endothelial cell density (ECD) at 12 months were also assessed. Results: Mean UDVA improved significantly in both groups at 12 months (all p < 0.05). Maximum keratometry (K-max) decreased by 1.04 ± 1.90 D in the CL-CXL group and by 0.87 ± 1.89 D in the A-CXL group at 12 months, which was not statistically significant (all p>0.05). Total corneal higher-order aberrations (HOAs) analysis showed a significant improvement in only the CL-CXL group at 12 months (p = 0.041). Average DLD was 227.18 ± 65.60 μm in the CL-CXL group and 245.30 ± 66.84 μm in the A-CXL group (p = 0.275). No significant change in ECD was found in either group (all p>0.05). Mean changes in UDVA, CDVA, K-max, K-mean, HOAs, and ECD were not statistically significant between the groups (all p>0.05). Conclusions: Silicone hydrogel CL-assisted CXL seems as effective as A-CXL in halting keratoconus progression in thin corneas with no side effects during the one-year follow-up period.
Databáze:	MEDLINE
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