Methotrexate Mechanism of Action in Plaque Psoriasis: Something New in the Old View.
| Autor: | El-Esawy FM; Drs. Salem and El-Esawy are with the Dermatology Department and Faculty of Medicine at Benha University, in Banha, Egypt., Ahmed IA; Dr. Ahmed is with Medical Biochemistry and Molecular Biology, Faculty of Medicine at Benha University in Banha, Egypt., El-Fallah AA; Dr. El-Fallah is Assistant Professor of Clinical and Chemical Pathology with the Faculty of Medicine at Benha University in Banha, Egypt., Salem RM; Drs. Salem and El-Esawy are with the Dermatology Department and Faculty of Medicine at Benha University, in Banha, Egypt. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of clinical and aesthetic dermatology [J Clin Aesthet Dermatol] 2022 Aug; Vol. 15 (8), pp. 42-46. |
| Abstrakt: | Background: Despite the era of biologic therapy in the management of psoriasis, methotrexate, the traditional backbone of psoriasis treatment, does not stop surprising us with what it can offer. Objective: In this study, we aimed to evaluate the peripheral expression and the serum levels of TWEAK in patients with psoriasis vulgaris before and after receiving methotrexate treatment. Methods: The study included 58 patients with moderate to severe psoriasis vulgaris, and 90 apparently healthy individuals as a control group. Before starting the treatment course, all patients were evaluated clinically using Psoriasis Area Severity Index (PASI) score and were subjected to TWEAK serum levels and peripheral expression measurement using ELISA and qRT-PCR techniques, respectively. After 12 weeks of treatment with methotrexate (intramuscular methotrexate; up to 30mg per week) the patients were re-evaluated both clinically and in the laboratory. Results: The baseline serum TWEAK levels and its peripheral mRNA expression in the patients group were significantly lower than those in the control group. After 12 weeks of treatment with methotrexate, the PASI scores were reduced significantly while the serum TWEAK levels and its peripheral expression were significantly elevated. Conclusion: Enhancing TWEAK expression and elevating its serum levels in psoriasis patients seems to be a newly observed mechanism of action of methotrexate. Competing Interests: DISCLOSURES: The authors report no conflicts of interest relevant to the content of this article. (Copyright © 2022. Matrix Medical Communications. All rights reserved.) |
| Databáze: | MEDLINE |
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