Multidimensional pain phenotypes after Traumatic Brain Injury.

Autor:	Robayo LE; Neuroscience Graduate Program, University of Miami Miller School of Medicine, Miami, FL, United States.; Christine E. Lynn Rehabilitation Center, Miami Project to Cure Paralysis at UHealth/Jackson Memorial, Miami, FL, United States., Govind V; Department of Radiology, Miller School of Medicine, University of Miami, Miami, FL, United States., Vastano R; Christine E. Lynn Rehabilitation Center, Miami Project to Cure Paralysis at UHealth/Jackson Memorial, Miami, FL, United States.; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, United States., Felix ER; Department of Physical Medicine and Rehabilitation, University of Miami Miller School of Medicine, Miami, FL, United States., Fleming L; Christine E. Lynn Rehabilitation Center, Miami Project to Cure Paralysis at UHealth/Jackson Memorial, Miami, FL, United States.; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, United States., Cherup NP; Christine E. Lynn Rehabilitation Center, Miami Project to Cure Paralysis at UHealth/Jackson Memorial, Miami, FL, United States.; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, United States., Widerström-Noga E; Neuroscience Graduate Program, University of Miami Miller School of Medicine, Miami, FL, United States.; Christine E. Lynn Rehabilitation Center, Miami Project to Cure Paralysis at UHealth/Jackson Memorial, Miami, FL, United States.; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in pain research (Lausanne, Switzerland) [Front Pain Res (Lausanne)] 2022 Aug 19; Vol. 3, pp. 947562. Date of Electronic Publication: 2022 Aug 19 (Print Publication: 2022).
DOI:	10.3389/fpain.2022.947562
Abstrakt:	More than 50% of individuals develop chronic pain following traumatic brain injury (TBI). Research suggests that a significant portion of post-TBI chronic pain conditions is neuropathic in nature, yet the relationship between neuropathic pain, psychological distress, and somatosensory function following TBI is not fully understood. This study evaluated neuropathic pain symptoms, psychological and somatosensory function, and psychosocial factors in individuals with TBI (TBI, N = 38). A two-step cluster analysis was used to identify phenotypes based on the Neuropathic Pain Symptom Inventory and Beck's Anxiety Inventory scores. Phenotypes were then compared on pain characteristics, psychological and somatosensory function, and psychosocial factors. Our analyses resulted in two different neuropathic pain phenotypes: (1) Moderate neuropathic pain severity and anxiety scores (MNP-AS, N = 11); and (2) mild or no neuropathic pain symptoms and anxiety scores (LNP-AS, N = 27). Furthermore, the MNP-AS group exhibited greater depression, PTSD, pain severity, and affective distress scores than the LNP-AS group. In addition, thermal somatosensory function (difference between thermal pain and perception thresholds) was significantly lower in the MNP-AS compared to the LNP-AS group. Our findings suggest that neuropathic pain symptoms are relatively common after TBI and are not only associated with greater psychosocial distress but also with abnormal function of central pain processing pathways. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Robayo, Govind, Vastano, Felix, Fleming, Cherup and Widerström-Noga.)
Databáze:	MEDLINE
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