Measuring catatonia motor behavior with objective instrumentation.

Autor:	von Känel S; Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland., Nadesalingam N; Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland.; Graduate School for Health Sciences (GHS), University of Bern, Bern, Switzerland., Alexaki D; Klinik Sonnenhalde, Basel, Switzerland., Baumann Gama D; Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland., Kyrou A; Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland., Lefebvre S; Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland., Walther S; Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland.
Jazyk:	angličtina
Zdroj:	Frontiers in psychiatry [Front Psychiatry] 2022 Aug 17; Vol. 13, pp. 880747. Date of Electronic Publication: 2022 Aug 17 (Print Publication: 2022).
DOI:	10.3389/fpsyt.2022.880747
Abstrakt:	Objective: Catatonia is a neuropsychiatric syndrome, with important psychomotor features, associated with schizophrenia and other psychiatric disorders. The syndrome comprises multiple symptoms including abnormal motor control, behaviors, volition, and autonomic regulation. Catatonia assessment relies on clinical rating scales and clinicians familiar with the catatonia exam. However, objective instrumentation may aid the detection of catatonia. We aimed to investigate the relationship between movement parameters derived from actigraphy and expert ratings of catatonia symptoms measured by the Bush Francis Catatonia Rating Scale (BFCRS) and the Northoff Catatonia scale (NCS). Methods: Eighty-six acutely ill inpatients with schizophrenia spectrum disorders were assessed with the BFCRS, the NCS, and 24 h continuous actigraphy. Non-wear and sleep periods were removed from the actigraphy data prior to analysis. Associations between total catatonia scores, derived from both BFCRS and NCS, and actigraphy parameters as well as between single BFCRS items and actigraphy parameters were calculated using Spearman's rank correlation and non-parametric ANCOVAs (Quade's ANCOVAs), respectively. Results: Both higher BFCRS total scores ( r = 0.369, p = 0.006) and NCS total scores ( r = 0.384, p = 0.004) were associated with lower activity levels (AL). Higher scores on single BFCRS items such as immobility/stupor or staring were linked to lower AL ( immobility/stupor : F = 17.388, p < 0.001, η 2 = 0.175; staring : F = 7.849, p = 0.001, η 2 = 0.162) and lower metabolic equivalents of task (MET). Conclusion: Specific catatonia symptoms such as immobility/stupor and staring can be measured with actigraphy. This may aid the detection, staging, and monitoring of catatonia in clinical settings. Competing Interests: SW received honoraria from Janssen, Lundbeck, Mepha, Neurolite, and Sunovion, which were unrelated to this work. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 von Känel, Nadesalingam, Alexaki, Baumann Gama, Kyrou, Lefebvre and Walther.)
Databáze:	MEDLINE
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