Protective Effect of Tilia americana var. mexicana Against Kainic Acid-induced Damage in Brain, Liver, and Kidney: Behavioral and Biochemical Changes.

Autor:	Coballase-Urrutia E; Laboratory of Neuroscience, National Institute of Pediatrics, Mexico City, Mexico., Cárdenas-Rodríguez N; Laboratory of Neuroscience, National Institute of Pediatrics, Mexico City, Mexico., Carmona-Aparicio L; Laboratory of Neuroscience, National Institute of Pediatrics, Mexico City, Mexico., Sánchez-Valle V; Laboratory of Neuroscience, National Institute of Pediatrics, Mexico City, Mexico.; Neuroplasticity and Neurodegeneration Laboratory, Department of Pharmacology, Center for Research and Advanced Studies, Mexico City, Mexico., Rivera-Espinosa L; Laboratory of Pharmacology, National Institute of Pediatrics, Mexico City, Mexico., Pedraza-Chaverri J; Department of Biology, Faculty of Chemistry, UNAM, Mexico City, Mexico., Montesinos-Correa H; Service of Endocrinology, National Institute of Pediatrics, Mexico City, Mexico., Bello-Robles E; Laboratory of Neuroscience, National Institute of Pediatrics, Mexico City, Mexico., Sampieri AI; Department of Comparative Biology, Faculty of Sciences, UNAM, Mexico City, Mexico., Martínez-Vargas D; Laboratory Control and Regulation Neurophysiology, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City, Mexico., Granados-Rojas L; Laboratory of Neuroscience, National Institute of Pediatrics, Mexico City, Mexico., González-Trujano ME; Laboratory of Neuropharmacology of Natural Products, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City, Mexico.
Jazyk:	angličtina
Zdroj:	Iranian journal of pharmaceutical research : IJPR [Iran J Pharm Res] 2022 May 03; Vol. 21 (1), pp. e126914. Date of Electronic Publication: 2022 May 03 (Print Publication: 2022).
DOI:	10.5812/ijpr-126914
Abstrakt:	Tiliaamericana var. mexicana (Tilia) possesses anticonvulsant, antioxidant, neuroprotective, and hepatoprotective activities. The spectrum of anticonvulsant activity in status epilepticus models has not been sufficiently explored. We evaluated the effects of ethyl acetate (EAc), and methanol (ME) extracts on kainic acid (KA)-induced seizures by measuring rats'behavior (severity and latency) and lipoperoxidation in different brain areas (cerebellum, brain hemispheres, cortex, and medulla), kidneys, and liver. Male Wistar rats were administered KA (10 mg/kg, i.p.) after three days of pretreatment with Tilia extract (100 mg/kg). The EAc and ME Tilia extracts significantly decreased the severity of phase 1 and phase 2 seizures, respectively. The ME Tilia extract increased the latency to seizure (27 ± 2 min) compared to the control (13 ± 2 min). The ME and EAc Tilia extracts significantly prevented the increased lipid peroxidation caused by KA-induced seizures in the cerebellum, brain hemispheres, cortex, medulla, liver, and kidneys. The vehicle olive oil (OO) also showed anticonvulsant effects, decreasing the severity of seizures to phase 3 and lipoperoxidation levels in the cerebellum, brain hemispheres, cortex, medulla, liver, and kidneys. The anticonvulsant activity of Tilia is mediated by antioxidant effects in central and systemic areas that involve synergistic interactions among the chemical constituents of these extracts (glucosides of quercetin and kaempferol), while vehicle OO showed the same effects, probably due to its constituent oleuropein. Competing Interests: Conflict of Interests: The authors declare that there are no conflicts of interest regarding the publication of this paper. (Copyright © 2022, Author(s).)
Databáze:	MEDLINE
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