Sexual maturation of HIV-infected and uninfected male children in Abakaliki, South-East, Nigeria: a cross-sectional study.
| Autor: | Ogeh CO; Alex-Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria., Orji ML; Alex-Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria., Iloh KK; Department of Paediatrics, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria., Nweke CJ; Alex-Ekwueme Federal University, Ndufu-Aleke Ikwo, Ebonyi State, Nigeria., Ogeh BU; Alex-Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria., Iloh ON; Department of Paediatrics, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria., Emodi IJ; Department of Paediatrics, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria. |
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| Jazyk: | angličtina |
| Zdroj: | The Pan African medical journal [Pan Afr Med J] 2022 Jun 17; Vol. 42, pp. 133. Date of Electronic Publication: 2022 Jun 17 (Print Publication: 2022). |
| DOI: | 10.11604/pamj.2022.42.133.29305 |
| Abstrakt: | Introduction: HIV infection, through various mechanisms causes a derangement in sexual maturation. This study compared the Marshal and Tanner staging of HIV-infected and uninfected males. The aim of the study was to determine the sexual maturation in male children infected with HIV on HAART in Abakaliki. Methods: this was a cross-sectional and comparative study involving 80 HIV-infected boys aged 8-17 years and 80 uninfected counterparts matched for age and socio-economic class. Stages of sexual maturation (testicular size and pubic hair) were determined according to the method proposed by Marshall and Tanner. The testicular size was measured using an orchidometer. Data analysis was done with SPSS version 20. Structured questionnaire was used to collect information on socio-demographics. Results: assessment of pubic hair development, showed that 45 (56.2%) of the subjects were in the pre-pubertal stage compared to 27 (33.8%) among the controls, this relationship was statistically significant (p=0.005, OR = 2.5, C.I=1.3-4.8). The mean testicular volume among subjects was found to be 8.29 ± 8.26mls compared to 11.57 ± 8.26mls found in controls. This relationship was also statistically significant. There were significant statistical relationships between duration on HAART and clinical stages of disease with both pubic hair development and testicular volume of subjects and controls. Conclusion: HIV-infected males had significantly delayed onset and progression of sexual maturation. Routine assessment of the sexual maturation of HIV-infected children as well as addressing the modifiable variables influencing sexual maturity is recommended. Competing Interests: The authors declare no competing interests. (Copyright: Chijioke Ogodo Ogeh et al.) |
| Databáze: | MEDLINE |
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