Sustained COVID-19 community transmission and potential super spreading events at neglected afro-ecuadorian communities assessed by massive RT-qPCR and serological testing of community dwelling population.

Autor:	Vallejo-Janeta AP; One Health Research Group, Universidad de Las Américas, Quito, Ecuador., Morales-Jadan D; One Health Research Group, Universidad de Las Américas, Quito, Ecuador., Paredes-Espinosa MB; One Health Research Group, Universidad de Las Américas, Quito, Ecuador., Coronel B; 'UDLA-COVID-19 Team', Universidad de Las Américas, Quito, Ecuador., Galvis H; 'UDLA-COVID-19 Team', Universidad de Las Américas, Quito, Ecuador., Bone-Guano HR; Universidad Técnica Luis Vargas Torres, Esmeraldas, Ecuador., Amador Rodriguez B; Universidad Técnica Luis Vargas Torres, Esmeraldas, Ecuador., Gomez Abeledo G; Universidad Técnica Luis Vargas Torres, Esmeraldas, Ecuador., Freire-Paspuel B; 'UDLA-COVID-19 Team', Universidad de Las Américas, Quito, Ecuador., Ortiz-Prado E; One Health Research Group, Universidad de Las Américas, Quito, Ecuador., Rivera-Olivero I; One Health Research Group, Universidad de Las Américas, Quito, Ecuador., Henriquez-Trujillo AR; One Health Research Group, Universidad de Las Américas, Quito, Ecuador., Lozada T; Decanato de Investigación y Vinculación, Universidad de Las Américas, Quito, Ecuador., Bereguiain MAG; One Health Research Group, Universidad de Las Américas, Quito, Ecuador.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2022 Aug 18; Vol. 9, pp. 933260. Date of Electronic Publication: 2022 Aug 18 (Print Publication: 2022).
DOI:	10.3389/fmed.2022.933260
Abstrakt:	Background: Neglected ethnic minorities from underserved rural populations in Latin America are highly vulnerable to coronavirus disease 2019 (COVID-19) due to poor health infrastructure and limited access to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnosis. Esmeraldas is a mainly rural province of the Coastal Region of Ecuador characterized by a high presence of Afro-Ecuadorian population living under poverty conditions. Objective: We herein present a retrospective analysis of the surveillance SARS-CoV-2 testing in community-dwelling population from Esmeraldas carried out by our university laboratory in collaboration with regional health authorities during the first week of October 2020, in a region where no public SARS-CoV-2 detection laboratory was available at that time. Results: A total number of 1,259 people were tested for SARS-CoV-2 by Reverse Transcription quantitative Polimerasa Chain Reaction (RT-qPCR), resulting in an overall infection rate of 7.7% (97/1259, 95% CI : [6.32-9.35%]) for SARS-CoV-2, up to 12.1% in some communities. Interestingly, community-dwelling super spreaders with viral loads over 10 8 copies/ml represented 6.2% of the SARS-CoV-2-infected population. Furthermore, anti-SARS-CoV-2 IgG serological tests were applied to the same study group, yielding an overall seroprevalence of 11.68% (95% CI : [9.98-13.62%]) but as high as 24.47% at some communities. Conclusion: These results support active COVID-19 community transmission in Esmeraldas province during the first semester of the COVID-19 pandemic as it has been shown for other rural communities in the Ecuadorian Coastal Region. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Vallejo-Janeta, Morales-Jadan, Paredes-Espinosa, Coronel, Galvis, Bone-Guano, Amador Rodriguez, Gomez Abeledo, Freire-Paspuel, Ortiz-Prado, Rivera-Olivero, Henriquez-Trujillo, Lozada, Bereguiain and the UDLA COVID-19 Team.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu