Antiretroviral drug-drug interactions: A comparison of online drug interaction databases.

Autor: Drwiega EN; College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA., Badowski ME; College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA., Michienzi S; College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA.
Jazyk: angličtina
Zdroj: Journal of clinical pharmacy and therapeutics [J Clin Pharm Ther] 2022 Oct; Vol. 47 (10), pp. 1720-1724. Date of Electronic Publication: 2022 Sep 04.
DOI: 10.1111/jcpt.13750
Abstrakt: What Is Known and Objective: Antiretrovirals have a high drug interaction potential, which can lead to increased toxicity and/or decreased efficacy. Multiple databases are available to assess drug-drug interactions. The aim of our study was to compare interaction identification for commonly used ARVs and concomitant medications between six different online drug-drug interaction databases.
Comment: This was a cross-sectional review using each of the following six databases: LexiComp®, Clinical Pharmacology®, Micromedex®, Epocrates®, University of Liverpool, and University of Toronto. Sixteen antiretroviral drugs and 100 of the DrugStats Database "Top 200 of 2019" list of medications were included. Each of the six databases identified a different number of actual or potential interactions. The number of interactions ranged from 211 to 283.
What Is New and Conclusions: A variety of databases exist with inconsistent identification of actual or potential drug-drug interactions amongst them. It may be beneficial to cross-reference multiple databases prior to making decisions regarding patient care.
(© 2022 The Authors. Journal of Clinical Pharmacy and Therapeutics published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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