Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers.

Autor: Zakiniaeiz Y; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Yale Positron Emission Tomography (PET) Center, Yale School of Medicine, New Haven, CT, USA. Electronic address: yasmin.zakiniaeiz@yale.edu., Hoye J; Yale Positron Emission Tomography (PET) Center, Yale School of Medicine, New Haven, CT, USA; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA., Ryan Petrulli J; Yale Positron Emission Tomography (PET) Center, Yale School of Medicine, New Haven, CT, USA; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA., LeVasseur B; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA., Stanley G; Yale Positron Emission Tomography (PET) Center, Yale School of Medicine, New Haven, CT, USA; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA., Gao H; Yale Positron Emission Tomography (PET) Center, Yale School of Medicine, New Haven, CT, USA; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA., Najafzadeh S; Yale Positron Emission Tomography (PET) Center, Yale School of Medicine, New Haven, CT, USA; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA., Ropchan J; Yale Positron Emission Tomography (PET) Center, Yale School of Medicine, New Haven, CT, USA; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA., Nabulsi N; Yale Positron Emission Tomography (PET) Center, Yale School of Medicine, New Haven, CT, USA; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA., Huang Y; Yale Positron Emission Tomography (PET) Center, Yale School of Medicine, New Haven, CT, USA; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA., Chen MK; Yale Positron Emission Tomography (PET) Center, Yale School of Medicine, New Haven, CT, USA; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA., Matuskey D; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Yale Positron Emission Tomography (PET) Center, Yale School of Medicine, New Haven, CT, USA; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA., Barron DS; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Department of Psychiatry, Brigham & Women's Hospital, Boston, MA, USA; Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham & Women's Hospital, Boston, MA, USA., Kelmendi B; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA., Fulbright RK; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA., Hampson M; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA; Department of Biomedical Engineering, Yale School of Medicine, New Haven, CT, USA., Cosgrove KP; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Yale Positron Emission Tomography (PET) Center, Yale School of Medicine, New Haven, CT, USA., Morris ED; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA; Yale Positron Emission Tomography (PET) Center, Yale School of Medicine, New Haven, CT, USA; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA; Department of Psychiatry, Brigham & Women's Hospital, Boston, MA, USA.
Jazyk: angličtina
Zdroj: Brain, behavior, and immunity [Brain Behav Immun] 2022 Nov; Vol. 106, pp. 262-269. Date of Electronic Publication: 2022 Sep 01.
DOI: 10.1016/j.bbi.2022.08.016
Abstrakt: Immune-brain interactions influence the pathophysiology of addiction. Lipopolysaccharide (LPS)-induced systemic inflammation produces effects on reward-related brain regions and the dopamine system. We previously showed that LPS amplifies dopamine elevation induced by methylphenidate (MP), compared to placebo (PBO), in eight healthy controls. However, the effects of LPS on the dopamine system of tobacco smokers have not been explored. The goal of Study 1 was to replicate previous findings in an independent cohort of tobacco smokers. The goal of Study 2 was to combine tobacco smokers with the aforementioned eight healthy controls to examine the effect of LPS on dopamine elevation in a heterogenous sample for power and effect size determination. Eight smokers were each scanned with [ 11 C]raclopride positron emission tomography three times-at baseline, after administration of LPS (0.8 ng/kg, intravenously) and MP (40 mg, orally), and after administration of PBO and MP, in a double-blind, randomized order. Dopamine elevation was quantified as change in [ 11 C]raclopride binding potential (ΔBP ND ) from baseline. A repeated-measures ANOVA was conducted to compare LPS and PBO conditions. Smokers and healthy controls were well-matched for demographics, drug dosing, and scanning parameters. In Study 1, MP-induced striatal dopamine elevation was significantly higher following LPS than PBO (p = 0.025, 18 ± 2.9 % vs 13 ± 2.7 %) for smokers. In Study 2, MP-induced striatal dopamine elevation was also significantly higher under LPS than under PBO (p < 0.001, 18 ± 1.6 % vs 11 ± 1.5 %) in the combined sample. Smoking status did not interact with the effect of condition. This is the first study to translate the phenomenon of amplified dopamine elevation after experimental activation of the immune system to an addicted sample which may have implications for drug reinforcement, seeking, and treatment.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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