Evaluation of chitosan/xanthan gum polyelectrolyte complexes potential for pH-dependent oral delivery of escin.

Autor: Ćirić A; University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: ana.ciric@pharmacy.bg.ac.rs., Budinčić JM; University of Novi Sad, Faculty of Technology, Department of Biotechnology and Pharmaceutical Engineering, Boulevard cara Lazara 1, 21102 Novi Sad, Serbia. Electronic address: jelenamilinkovic@tf.uns.ac.rs., Medarević Đ; University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: djordje.medarevic@pharmacy.bg.ac.rs., Dobričić V; University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: vladimir.dobricic@pharmacy.bg.ac.rs., Rmandić M; University of Belgrade, Faculty of Pharmacy, Department of Drug Analysis, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: milena.rmandic@pharmacy.bg.ac.rs., Barudžija T; University of Belgrade, Vinča Institute of Nuclear Sciences, Laboratory for Theoretical Physics and Condensed Matter Physics, Mike Petrovića Alasa 12-14, 11351 Belgrade, Serbia. Electronic address: tbarudzija@vin.bg.ac.rs., Malenović A; University of Belgrade, Faculty of Pharmacy, Department of Drug Analysis, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: andjelija.malenovic@pharmacy.bg.ac.rs., Petrović L; University of Novi Sad, Faculty of Technology, Department of Biotechnology and Pharmaceutical Engineering, Boulevard cara Lazara 1, 21102 Novi Sad, Serbia. Electronic address: lidijap@uns.ac.rs., Djekic L; University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: ljiljanadjek@gmail.com.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2022 Nov 30; Vol. 221, pp. 48-60. Date of Electronic Publication: 2022 Sep 02.
DOI: 10.1016/j.ijbiomac.2022.08.190
Abstrakt: Escin is an amphiphilic and weakly acidic drug that oral administration may lead to the irritation of gastric mucosa. The entrapment of escin into chitosan (CH)/xanthan gum (XG)-based polyelectrolyte complexes (PECs) can facilitate controlled drug release which may be beneficial for the reduction of its side effects. This study aimed to investigate the influence of escin content and drying method on the formation, physicochemical, and controlled, pH-dependent drug release properties of CH/XG-based PECs. Measurements of transmittance, conductivity, and rheological characterization confirmed the formation of CH/XG-based PECs with escin entrapped at escin-to-polymers mass ratios 1:1, 1:2, and 1:4. Ambient-dried PECs had higher yield, entrapment efficiency, and escin content in comparison with spray-dried ones. FT-IR spectra confirmed the interactions between CH, XG, and escin, which were stronger in ambient-dried PECs. PXRD and DSC analyses showed the amorphous escin character in all dry PECs, regardless of the drying method. The most promising controlled and pH-dependent in vitro escin release was from the ambient-dried PEC at the escin-to-polymers mass ratio of 1:1. For that reason and due to the highest yield and entrapment efficiency, this carrier has the potential to prevent the irritation of gastric mucosa after oral administration of escin.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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