Associations between urinary biomarkers of oxidative stress and biomarkers of tobacco smoke exposure in smokers.

Autor: Sambiagio N; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Epalinges, Lausanne, Switzerland. Electronic address: nicolas.sambiagio@unisante.ch., Berthet A; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Epalinges, Lausanne, Switzerland. Electronic address: aurelie.berthet@unisante.ch., Wild P; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Epalinges, Lausanne, Switzerland. Electronic address: pascal@pw-statistical-consulting.eu., Sauvain JJ; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Epalinges, Lausanne, Switzerland. Electronic address: jeanjacques.sauvain@unisante.ch., Auer R; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Epalinges, Lausanne, Switzerland; Institute of Primary Health Care (BIHAM), University of Bern, Mittelstrasse 43, 3012 Bern, Switzerland. Electronic address: reto.auer@biham.unibe.ch., Schoeni A; Institute of Primary Health Care (BIHAM), University of Bern, Mittelstrasse 43, 3012 Bern, Switzerland. Electronic address: anna.schoeni@biham.unibe.ch., Rodondi N; Institute of Primary Health Care (BIHAM), University of Bern, Mittelstrasse 43, 3012 Bern, Switzerland; Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, 3010 Bern, Switzerland. Electronic address: nicolas.rodondi@biham.unibe.ch., Feller M; Institute of Primary Health Care (BIHAM), University of Bern, Mittelstrasse 43, 3012 Bern, Switzerland; Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, 3010 Bern, Switzerland., Humair JP; Department of Primary Care Medicine, Geneva University Hospitals, Rue Gabrielle Perret-Gentil 4, 1211 Geneva, Switzerland. Electronic address: jean-paul.humair@hcuge.ch., Berlin I; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Epalinges, Lausanne, Switzerland; Department of Pharmacology, Assistance Publique-Hôpitaux de Paris, Sorbonne University, 75013 Paris, France. Electronic address: ivan.berlin@aphp.fr., Breider F; Central Environmental Laboratory (GR-CEL), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland. Electronic address: florian.breider@epfl.ch., Grandjean D; Central Environmental Laboratory (GR-CEL), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne CH-1015, Switzerland. Electronic address: dominique.grandjean@epfl.ch., Hopf NB; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Epalinges, Lausanne, Switzerland. Electronic address: nancy.hopf@unisante.ch.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2022 Dec 15; Vol. 852, pp. 158361. Date of Electronic Publication: 2022 Sep 02.
DOI: 10.1016/j.scitotenv.2022.158361
Abstrakt: Oxidative stress can contribute to the development of diseases, and may originate from exposures to toxicants commonly found in air pollution and cigarette smoke such as polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs). Yet, associations between these exposures and oxidative stress biomarkers are poorly characterized. We report here novel associations between 14 exposure biomarkers of PAHs and VOCs, and two oxidative stress biomarkers; 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-isoprostaglandin F 2α (8-isoprostane) in urine obtained from smokers participating in an ongoing clinical study (ESTxENDS, NCT03589989). We also assessed associations between six biomarkers of tobacco smoke exposure (metabolites of nicotine and tobacco-specific nitrosamines (TSNAs)) and both oxidative stress biomarkers. We then quantified the relative importance of each family of the 20 exposure biomarkers on oxidative stress. Participating smokers (153 men and 117 women, median age 44 years) had on average smoked 25 [2-62] years and smoked about 17 [5-40] cigarettes per day at the time of the study. Multiple linear regression results showed an association between 8-oxodG concentrations and the following metabolites in decreasing relative importance: PAHs (beta coefficient β = 0.105, p-value <0.001, partial R 2 = 0.15) > VOCs (β = 0.028, p < 0.001, partial R 2 = 0.09) > nicotine (β = 0.226, p < 0.001, partial R 2 = 0.08); and between 8-isoprostane concentrations and metabolites of PAHs (β = 0.117, p < 0.001, partial R 2 = 0.14) > VOCs (β = 0.040, p < 0.001, partial R 2 = 0.14) > TSNAs (β = 0.202, p = 0.003, partial R 2 = 0.09) > nicotine (β = 0.266, p < 0.001, partial R 2 = 0.08). Behavioral factors known to contribute to oxidative stress, including sleep quality, physical activity, and alcohol consumption, did not play a significant role. Exposures to PAHs and VOCs among smokers were significantly associated with oxidative stress.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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