Pathogen diversity, immunity, and the fate of infections: lessons learned from Trypanosoma cruzi human-host interactions.
| Autor: | Magalhães LMD; Departamento de Morfologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Gollob KJ; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Belo Horizonte, Brazil; Hospital Israelita Albert Einstein, São Paulo, Brazil., Zingales B; Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil., Dutra WO; Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais, Belo Horizonte, Brazil. Electronic address: waldutra@icb.ufmg.br. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | The Lancet. Microbe [Lancet Microbe] 2022 Sep; Vol. 3 (9), pp. e711-e722. Date of Electronic Publication: 2022 Mar 10. |
| DOI: | 10.1016/S2666-5247(21)00265-2 |
| Abstrakt: | The complexity of host-pathogen interactions often leads to distinct clinical outcomes upon infection with different pathogen strains. In this Review, we explore the interactions between the highly diverse Trypanosoma cruzi population and the human host. At least 30% of the 7 million individuals with Chagas disease will develop a severe cardiopathy that is among the deadliest heart diseases known. The diversity of the T cruzi population also creates major hurdles for therapy and vaccine development. We also discuss the ecoepidemiological and geographical distribution of T cruzi strains, their susceptibility to treatment, their antigenic diversity, and their effect on the immune response and on disease outcome. Furthermore, we highlight the importance of understanding the T cruzi host-pathogen relationship for guiding new approaches towards development of therapies and vaccines for Chagas disease, and how the information gained by studying this relationship can inspire solutions for other host-pathogen interactions. Competing Interests: Declaration of interests We declare no competing interests. (Copyright © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|