Multimorbidity patterns and subgroups among autistic adults with intellectual disability: Results from the EFAAR study.

Autor:	Miot S; Department of Gerontology and Geriatrics, Montpellier University Hospital, MUSE University, Montpellier, France.; CESP, INSERM U1178, Centre de recherche en Epidemiologie et Santé des Populations, Villejuif, France., Chancel R; Department of Gerontology and Geriatrics, Montpellier University Hospital, MUSE University, Montpellier, France.; Autism Reference Centre of Languedoc-Roussillon CRA-LR, Excellence Centre for Autism and Neurodevelopmental disorders CeAND, Montpellier University Hospital, MUSE University, France., Peries M; Department of Gerontology and Geriatrics, Montpellier University Hospital, MUSE University, Montpellier, France.; Autism Reference Centre of Languedoc-Roussillon CRA-LR, Excellence Centre for Autism and Neurodevelopmental disorders CeAND, Montpellier University Hospital, MUSE University, France., Crepiat S; Autism Reference Centre of Languedoc-Roussillon CRA-LR, Excellence Centre for Autism and Neurodevelopmental disorders CeAND, Montpellier University Hospital, MUSE University, France., Couderc S; Autism Reference Centre of Languedoc-Roussillon CRA-LR, Excellence Centre for Autism and Neurodevelopmental disorders CeAND, Montpellier University Hospital, MUSE University, France., Pernon E; Department of Gerontology and Geriatrics, Montpellier University Hospital, MUSE University, Montpellier, France.; Autism Reference Centre of Languedoc-Roussillon CRA-LR, Excellence Centre for Autism and Neurodevelopmental disorders CeAND, Montpellier University Hospital, MUSE University, France., Picot MC; Department of Gerontology and Geriatrics, Montpellier University Hospital, MUSE University, Montpellier, France.; CESP, INSERM U1178, Centre de recherche en Epidemiologie et Santé des Populations, Villejuif, France., Gonnier V; Autism Reference Centre of Languedoc-Roussillon CRA-LR, Excellence Centre for Autism and Neurodevelopmental disorders CeAND, Montpellier University Hospital, MUSE University, France., Jeandel C; Department of Gerontology and Geriatrics, Montpellier University Hospital, MUSE University, Montpellier, France., Blain H; Department of Gerontology and Geriatrics, Montpellier University Hospital, MUSE University, Montpellier, France., Baghdadli A; Department of Gerontology and Geriatrics, Montpellier University Hospital, MUSE University, Montpellier, France.; CESP, INSERM U1178, Centre de recherche en Epidemiologie et Santé des Populations, Villejuif, France.; Autism Reference Centre of Languedoc-Roussillon CRA-LR, Excellence Centre for Autism and Neurodevelopmental disorders CeAND, Montpellier University Hospital, MUSE University, France.
Jazyk:	angličtina
Zdroj:	Autism : the international journal of research and practice [Autism] 2023 Apr; Vol. 27 (3), pp. 762-777. Date of Electronic Publication: 2022 Sep 02.
DOI:	10.1177/13623613221121623
Abstrakt:	Lay Abstract: Multimorbidity relates to having multiple chronic health conditions. It is a risk factor for poor health and reduces life expectancy. Autistic people have multiple chronic health conditions and die prematurely, especially if they have an intellectual disability (autism spectrum disorder and intellectual disability). Certain pathophysiological processes observed in autism spectrum disorder are common to those related to the genesis and/or maintenance of multimorbidity. Furthermore, multimorbidity could be helpful in better identifying patient subgroups in autism spectrum disorder. It is therefore essential to better characterize multimorbidity and its consequences in the subgroup of autism spectrum disorder + intellectual disability individuals to offer them personalized care. We conducted a preliminary study of 63 autism spectrum disorder + intellectual disability adults to classify them according to their multimorbidity and search for a specific combination of chronic health conditions. We observed high and early multimorbidity in this sample and identified four classes of participants, distinguished by their multimorbidity status, independence and number of treatments. In addition, we observed a dominant combination of multimorbidity in our sample, combining immune dysfunction and gastrointestinal disorders, neurological and joint diseases. These findings support the hypothesis that an altered gut-brain relationship is involved in the risk of autism spectrum disorder, its outcome, and its association with chronic health conditions. Although larger studies are needed, our results suggest that subgroups of autism spectrum disorder + intellectual disability individuals can be identified based on their multimorbidity and potentially different ageing trajectories. A more comprehensive and personalized approach is needed to reduce the burden of multimorbidity and increase the quality of life and life expectancy in autism spectrum disorder/ intellectual disability.
Databáze:	MEDLINE
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