The impact of surgery and adjuvant chemotherapy on health-related quality of life in patients with colon cancer: Changes at group level versus individual level.

Autor:	Scheepers ERM; Department of Internal Medicine, Diakonessenhuis Utrecht, Utrecht, Netherlands., Vink GR; Department of medical oncology, University Medical Centre Utrecht, Utrecht University, Utrecht, Netherlands.; Department of Research, Netherlands Comprehensive Cancer Organisation, Utrecht, Netherlands., Schiphorst AHW; Department of Surgery, Diakonessenhuis Utrecht, Utrecht, Netherlands., Emmelot-Vonk MH; Department of Geriatric Medicine, University Medical Centre Utrecht, Utrecht, Netherlands., van Huis-Tanja LH; Department of Internal Medicine, Diakonessenhuis Utrecht, Utrecht, Netherlands., Hamaker ME; Department of Geriatric Medicine, Diakonessenhuis Utrecht, Utrecht, Netherlands.
Jazyk:	angličtina
Zdroj:	European journal of cancer care [Eur J Cancer Care (Engl)] 2022 Nov; Vol. 31 (6), pp. e13691. Date of Electronic Publication: 2022 Sep 02.
DOI:	10.1111/ecc.13691
Abstrakt:	Objective: This study aims to evaluate changes in health-related quality of life (HR-QoL) 1 year after surgical treatment in patients with primary resectable colon cancer and to assess whether changes at group level differ from changes at individual level. In addition, we assess which characteristics are associated with a decline of HR-QoL. Methods: Patients with primary resectable colon cancer who received surgical treatment and adjuvant chemotherapy if indicated were selected from the Prospective Dutch ColoRectal Cancer cohort (PLCRC). HR-QoL was assessed using EORTC-QLQ-C30 questionnaire before surgery and 12 months post-surgery. Outcomes were assessed at group and individual levels. Logistic regression analysis was conducted to assess which socio-demographic and clinical characteristics were associated with a clinically relevant decline of HR-QoL at 12 months. Results: Of all 324 patients, the baseline level of HR-QoL summary score was relatively high with a mean of 88.1 (SD 11.4). On group level, the change of HR-QoL at 12 months varied between -2% for cognitive functioning and +9% for emotional functioning. On individual level, 15% of all patients experienced a clinically relevant decline in HR-QoL summary score at 12 months. Older age, comorbidity burden or the reception of adjuvant chemotherapy was independently associated with a decline of HR-QoL in one of the functional subscales of EORTC-QLQ-C30 at 12 months. Conclusion: Only trivial changes of HR-QoL were observed after colon cancer treatment on group level, whereas on individual level, at least 1 out of 10 patients experienced a decline of HR-QoL 12 months post-surgery. It is important to consider individual differences while making a treatment decision. (© 2022 John Wiley & Sons Ltd.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu