Genome scanning of behavioral selection in a canine olfactory detection breeding cohort.

Autor: Eyre AW; Center for Clinical and Translational Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, 43205, USA., Zapata I; Department of Biomedical Sciences, Rocky Vista University College of Osteopathic Medicine, Parker, CO, 80134, USA., Hare E; Dog Genetics LLC, Astoria, NY, 11102, USA., Lee KMN; Division of Public Health Sciences, Department of Surgery, Washington University in St. Louis School of Medicine, St. Louis, USA.; Department of Anthropology, Tulane University, New Orleans, USA., Bellis C; Human Genomics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, 138672, Singapore.; Centre for Genomics and Personalised Health, Genomics Research Centre, School of Biomedical Sciences, Queensland University of Technology (QUT), Kelvin Grove, QLD, Australia., Essler JL; Penn Vet Working Dog Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19146, USA.; Department of Animal Science, State University of New York College of Agriculture and Technology at Cobleskill, New York, USA., Otto CM; Penn Vet Working Dog Center, Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19146, USA., Serpell JA; Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Alvarez CE; Center for Clinical and Translational Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, 43205, USA. alvarez.73@osu.edu.; Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, 43210, USA. alvarez.73@osu.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Sep 02; Vol. 12 (1), pp. 14984. Date of Electronic Publication: 2022 Sep 02.
DOI: 10.1038/s41598-022-18698-4
Abstrakt: Research on working dogs is growing rapidly due to increasing global demand. Here we report genome scanning of the risk of puppies being eliminated for behavioral reasons prior to entering the training phase of the US Transportation Security Administration's (TSA) canine olfactory detection breeding and training program through 2013. Elimination of dogs for behavioral rather than medical reasons was based on evaluations at three, six, nine and twelve months after birth. Throughout that period, the fostered dogs underwent standardized behavioral tests at TSA facilities, and, for a subset of tests, dogs were tested in four different environments. Using methods developed for family studies, we performed a case-control genome wide association study (GWAS) of elimination due to behavioral observation and testing results in a cohort of 528 Labrador Retrievers (2002-2013). We accounted for relatedness by including the pedigree as a covariate and maximized power by including individuals with phenotype, but not genotype, data (approximately half of this cohort). We determined genome wide significance based on Bonferroni adjustment of two quasi-likelihood score tests optimized for either small or nearly-fully penetrant effect sizes. Six loci were significant and five suggestive, with approximately equal numbers of loci for the two tests and frequencies of loci with single versus multiple mapped markers. Several loci implicate a single gene, including CHD2, NRG3 and PDE1A which have strong relevance to behavior in humans and other species. We briefly discuss how expanded studies of canine breeding programs could advance understanding of learning and performance in the mammalian life course. Although human interactions and other environmental conditions will remain critical, our findings suggest genomic breeding selection could help improve working dog populations.
(© 2022. The Author(s).)
Databáze: MEDLINE
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