Selective adipocyte loss of Angiopoietin-2 prompts female-specific obesity and metabolic syndrome.

Autor:	Ni B; Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Virginia Commonwealth University School of Medicine, Richmond, VA, USA; Central Virginia VA Health Care System (CVHCS)/McGuire VA Medical Center, Richmond, VA, USA., Chen S; Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Virginia Commonwealth University School of Medicine, Richmond, VA, USA; Department of Biostatistics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Ryan KA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Maitland ML; Section of Hematology/Oncology, Department of Medicine, and Committee on Clinical Pharmacology and Pharmacogenomics, University of Chicago Medicine and Biological Sciences, Chicago, IL, USA; Inova Center for Personalized Health, Inova Schar Cancer Institute, Falls Church, VA, USA., Farrar JS; Center for Clinical and Translational Research, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Witzenrath M; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany; German Center for Lung Research (DZL), Berlin, Germany., Gubier B; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany., Serdjebi C; Biocellvia, Marseille, France., Bertotti K; Biocellvia, Marseille, France., Wang R; Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Salloum FN; Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Marino L; Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Virginia Commonwealth University School of Medicine, Richmond, VA, USA., Mitchell BD; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA., Celi FS; Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, Virginia Commonwealth University School of Medicine, Richmond, VA, USA. Electronic address: francesco.celi@vcuhealth.org.
Jazyk:	angličtina
Zdroj:	Molecular metabolism [Mol Metab] 2022 Nov; Vol. 65, pp. 101588. Date of Electronic Publication: 2022 Aug 30.
DOI:	10.1016/j.molmet.2022.101588
Abstrakt:	Thermogenic fat differentiation and function can be promoted through multiple pathways, resulting in a common cell phenotype characterized by the expression of Uncoupling Protein-1 and the ability to dissipate energy, but local and systemic stimuli are necessary to promote adequate thermogenic fat vascularization, which is a precondition for the transport of substrate and the dissipation of heat. Angiopoietin-2 is an important driver of vascularization, and its transcription is in part promoted by estrogen signaling. In this study we demonstrate that adipose tissue-specific knock out of Angiopoietin-2 causes a female-specific reduced thermogenic fat differentiation and function, resulting in obesity and impaired glucose tolerance with end-organ features consistent with metabolic syndrome. In humans, angiopoietin-2 levels are higher in females than in males, and are inversely correlated with adiposity and age more strongly in pre-menopause when compared to post-menopause. Collectively, these data indicate a novel and important role for estrogen-mediated Angiopoietin-2 adipose tissue production in the protection against calorie overload in females, and potentially in the development of postmenopausal weight gain. (Copyright © 2022 The Author(s). Published by Elsevier GmbH.. All rights reserved.)
Databáze:	MEDLINE
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