The Warburg effect: Saturation of mitochondrial NADH shuttles triggers aerobic lactate fermentation.
| Autor: | Medeiros HCD; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA., Lunt SY; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA; Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, USA. Electronic address: sophia@msu.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Molecular cell [Mol Cell] 2022 Sep 01; Vol. 82 (17), pp. 3119-3121. |
| DOI: | 10.1016/j.molcel.2022.08.004 |
| Abstrakt: | In this issue of Molecular Cell, Wang et al. investigate the Warburg effect in proliferating cells and demonstrate that lactate fermentation is a secondary mechanism activated after mitochondrial shuttles exceed their capacity to oxidize cytosolic NADH. Competing Interests: Declaration of interests S.Y.L. is a member of the Van Andel Institute Metabolism & Nutrition Program Internal Advisory Board. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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