Cytotoxic activity of the crude polysaccharides/exopolysaccharides of Coprinus comatus and Coprinellus truncorum .

Autor: Atlagić K; Institute of Physiology and Biochemistry, Faculty of Biology, University of Belgrade, Belgrade, Serbia., Živić M; Institute of Physiology and Biochemistry, Faculty of Biology, University of Belgrade, Belgrade, Serbia., Jakovljević D; Department of Chemistry, Institute of Chemistry, Technology and Metallurgy - ICTM, University of Belgrade, Belgrade, Serbia., Marković Filipović J; Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia., Šibul F; Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia., Pejin B; Department of Life Sciences, Institute for Multidisciplinary Research - IMSI, University of Belgrade, Belgrade, Serbia., Karaman M; Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia.
Jazyk: angličtina
Zdroj: Natural product research [Nat Prod Res] 2023 Jun; Vol. 37 (11), pp. 1838-1843. Date of Electronic Publication: 2022 Sep 02.
DOI: 10.1080/14786419.2022.2118743
Abstrakt: Fungi are an important source of polysaccharides (PSH) and phenolic compounds (PC). Numerous studies have highlighted the beneficial effects of fungal consumption, but the impact of submerged cultivated mycelia (M) and filtrate (F) has not been fully investigated. We aimed to investigate the cytotoxic activity of isolated crude PSH and exopolysaccharides (ePSH) of submerged cultivated M and F of edible Coprinus comatus and Coprinellus truncorum species. Both PSH and ePSH exhibited significant cytotoxic activity towards HepG2 cancer cells of human origin (three-way ANOVA). The C. truncorum PSH/ePSH was more efficient inducing maximal reduction in cell viability (≈50% at 450 µg/mL) after 24 h while C. comatus PSH/ePSH needed 72 h to reach similar effect (≈60% at 450 µg/mL). Partial least square regression (PLSR) analysis indicated that specific phenolic composition of the PSH/ePSH could be responsible for the difference in their activity.
Databáze: MEDLINE
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