Strontium-loaded hydrogel scaffolds to promote gingival fibroblast function.

Autor:	Alsharif SB; Department of Oral Biology, University at Buffalo, The State University of New York, Buffalo, New York, USA.; Department of Periodontology, King Abdulaziz University, Jeddah, Saudi Arabia., Wali R; Department of Oral Biology, University at Buffalo, The State University of New York, Buffalo, New York, USA.; College of Dentistry, Umm Al-Qura University, Meca, Saudi Arabia., Vanyo ST; Department of Oral Biology, University at Buffalo, The State University of New York, Buffalo, New York, USA., Andreana S; Department of Restorative Dentistry, University at Buffalo, The State University of New York, Buffalo, New York, USA., Chen K; Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York, USA., Sheth B; Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York, USA., Swihart MT; Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York, USA., Dziak R; Department of Oral Biology, University at Buffalo, The State University of New York, Buffalo, New York, USA., Visser MB; Department of Oral Biology, University at Buffalo, The State University of New York, Buffalo, New York, USA.
Jazyk:	angličtina
Zdroj:	Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2023 Jan; Vol. 111 (1), pp. 6-14. Date of Electronic Publication: 2022 Aug 29.
DOI:	10.1002/jbm.a.37439
Abstrakt:	Dental implant clinical success is dependent on effective peri-implant tissue attachment to the trans-mucosal portion following placement. Modification of transmucosal implant surfaces can improve cellular adhesion and function leading to formation of an effective soft-tissue seal during healing, of which gingival fibroblasts are prominent cells to migrate to repair wounds and crucial for the development of a collagen rich connective tissue. Biocompatible loaded scaffold materials have been developed to allow local release of molecules with effective biological activity. Our previous studies indicate that strontium can promote gingival fibroblast metabolism, decrease apoptosis and support adhesion to titanium healing abutments. In this study, we developed a strontium-loaded alginate hydrogel scaffold which can be easily personalized to fit over any size and shape of implant transmucosal collar or healing abutment. Results indicate that biologically active strontium ions are effectively released from loaded alginate hydrogel material to promote fibroblast viability and migration to repair in vitro wounds similar to that of strontium citrate solution. Overall, this novel strontium-loaded alginate scaffold device displays good biocompatibility and functionality, demonstrating high potential as a system to provide local delivery of strontium to improve peri-implant mucosal healing following implant placement and clinical success. (© 2022 Wiley Periodicals LLC.)
Databáze:	MEDLINE
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