C allele in transforming growth factor-β1 rs1800471 gene polymorphisms might indicate a protective feature in encapsulating peritoneal sclerosis development.

Autor: Bora F; Department of Internal Medicine, Division of Nephrology, Akdeniz University Medical School, Antalya, Turkey., Aslan B; Department of Internal Medicine, Division of Nephrology, Akdeniz University Medical School, Antalya, Turkey., Sarı F; Department of Internal Medicine, Division of Nephrology, Akdeniz University Medical School, Antalya, Turkey., Yılmaz F; Department of Nephrology, Antalya Atatürk State Hospital, Antalya, Turkey., Ersoy FF; Department of Internal Medicine, Division of Nephrology, Akdeniz University Medical School, Antalya, Turkey., Köksoy S; Department of Medical Microbiology, Akdeniz University Medical School, Antalya, Turkey., Özdem S; Department of Basic Medical Sciences, Medical Biochemistry, Akdeniz University Medical School, Antalya, Turkey., Küçükçetin İÖ; Department of Basic Medical Sciences, Medical Biochemistry, Akdeniz University Medical School, Antalya, Turkey., Sipahioğlu M; Department of Internal Medicine, Division of Nephrology, Erciyes University Medical School, Kayseri, Turkey., Karakaya İ; Department of Internal Medicine, Division of Nephrology, Çukurova University Medical School, Adana, Turkey., Koç Y; Department of Internal Medicine, Division of Nephrology, Cumhuriyet University Medical School, Sivas, Turkey., Ulu MS; Department of Internal Medicine, Division of Nephrology Bahçeşehir University Medical School, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy [Ther Apher Dial] 2023 Apr; Vol. 27 (2), pp. 353-360. Date of Electronic Publication: 2022 Aug 24.
DOI: 10.1111/1744-9987.13913
Abstrakt: Introduction: Peritoneal fibrosis may progress in peritoneal dialysis (PD) patients to a fatal clinical condition called encapsulating peritoneal sclerosis (EPS). Transforming growth factor (TGF)-β plays a pivotal role in the pathogenesis of peritoneal fibrosis. We aimed to investigate the association among polymorphisms in the gene encoding TGF-β1, which were -509C/T (rs1800469), +869T/C (rs1982073), and +915G/C (rs1800471) in EPS patients.
Methods: A total of 16 PD patients who were clinically and radiologically diagnosed with EPS were enrolled and 22 age- and gender-matched PD patients were selected as the non-EPS group.
Results: G allele frequency at the rs1800471 gene polymorphism was significantly higher in the EPS group than non-EPS group (p = 0.005). Interestingly, the non-EPS group patients had CC or CG polymorphisms.
Conclusion: C allele in TGF-β1 rs1800471 gene polymorphisms might indicate a protective feature in EPS development. Knowing the presence of polymorphism may be effective in selecting renal replacement therapy in patients.
(© 2022 International Society for Apheresis and Japanese Society for Apheresis.)
Databáze: MEDLINE
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